Xe/air exposures were conducted before each test in the battery (except for elevated O-maze). Effect of acute and chronic xenon inhalation on erythropoietin, hematological parameters, and athletic performance. Rabinovich SA, Zavodilenko LA, Babikov AS. https://doi.org/10.1016/j.cpr.2009.01.003. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Int J Neuropsychopharmacol. N=1114 rats/treatment. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. 2008;106:91623. N=1114 rats/treatment. 2007;22:127586. Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia. CAS Before Part I]. Unable to load your collection due to an error, Unable to load your delegates due to an error. Wang CY, Cheng CW, Wang WH, Chen PS, Tzeng SF. Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental Parkinsonism. Drug information provided by: IBM Micromedex. Cite this article. Lee EJ, Choi SY, Kim E. NMDA receptor dysfunction in autism spectrum disorders. Anesthesiology. How does xenon produce anaesthesia? Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. *p<0.05 represent significant differences vs. Control group (Dunnetts multiple comparisons test). Death may result from errors in judgment, confusion, or loss of consciousness which prevent self-rescue. https://doi.org/10.1146/annurev.publhealth.28.021406.144007. By the end of xenon inhalation, slight hypertension was observed after all three doses (P < 0.05), with an increase in middle cerebral artery velocity (P < 0.05). Gill H, Thoresen M, Bishop S, Smit E, Liu X, Walloe L, et al. To assess the acute effects, seven subjects breathed three subanesthetic concentrations of xenon: 30% fraction of inspired xenon (FiXe) for 20 min, 50% FiXe for 5 min, and 70% FiXe for 2 min. In all of the previous studies animals were treated with 2570% Xe for at least 20min and up to 5h [22, 24, 38,39,40,41,42]. In series 1 we assessed the effects of acute subanesthetic doses of Xe on normal rats in a battery of behavioral tests. A recent clinical trial has shown that inhalation of 30% Xe within a delayed time frame after birth asphyxia is apparently safe for newborns [17]. In addition, xenon at 50%, but not nitrous oxide at 75 vol%, further decreases ischemic brain damage in the striatum (a subcortical structure that is known to be . Acta Neurobiol Exp. It appears that volatile agents preferentially potentiate GABA A receptors and two-pore domain K + channels, whereas the anaesthetic gases nitrous oxide and xenon inhibit N-methyl-d-aspartate channels.. Uptake and removal of inhalation agents from the body depends on the alveolar concentration of . Clipboard, Search History, and several other advanced features are temporarily unavailable. Effects of 70% xenon inhalation on CBF in rats are time-dependent. Post-hoc analysis revealed an increased number of attacks in VPA group in comparison with Cont (p=0.031) and Xe (p=0.016) groups (Fig. Article Meloni EG, Gillis TE, Manoukian J, Kaufman MJ. Also, it was shown that exposure to VPA from pnd 6 to pnd 12 at the dose of 150mg/kg didnt affect physical development of rats but led to the disruption of motor skills involved in object manipulation [52]. Invest Radiol. Currently, there is no cure available for autism [9]. On the other hand, inhalation of stable xenon is not believed to pose a risk because no signs of cerebral oligemia or ischemia were indicated in the AVDO 2 values. Wherein, the exposure to Xe didnt alter either normal locomotor activity nor the normal anxiety level of rats in the open field, elevated-plus and elevated O-maze tests. Journal of Translational Medicine If you notice any other effects, check with your healthcare professional. Data are presented as box and whiskers plot. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Behavioral modulatory effects of Xe are probably related to its generalized action on excitatory/inhibitory balance within the CNS. The increased climbing in the second half of the experiment may indicate an impaired inhibitory reaction (habituation) which is normally formed during the long testing session. Acute inhalations of Xe in VPA-exposed animals led to improvement in social behavior, decrease in exploratory motivation, and normalization of behavior in forced-swim test. 1982 Nov-Dec;13(6):750-8. doi: 10.1161/01.str.13.6.750. (32C), with or without inhalation of 50% xenon. 2009;69:42940. Anti-spasmodic comprising xenon PL375161A1 (en) * 2002-06-21: 2005-11-28: University Of Pittsburgh Of The Commonwealth System Of Higher Education . 2007;28:23558. https://doi.org/10.1093/bja/aeg232. Animal models that recapitulate glutamatergic neurotransmission deficitswith corresponding autism-like behavioral readoutsare useful in evaluating novel therapies that could be translated to the treatment of autism [8]. The data on motor activity of rodents in VPA models of ASD are quite conflicting. Franks NP, Dickinson R, De Sousa SLM, Hall AC, Lieb WR. It's an expensive substance which can be found at a very low concentration in the air. Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. In vitro and in vivo studies prove that Xenon has therapeutic effects on various neurodegenerative outcomes. Find methods information, sources, references or conduct a . The normally distributed data are expressed as meanstandard error of the mean (SEM), and non-normal dataas the box and whiskers plot. Anesthesiology. J Appl Physiol (1985). Thus, it remains unclear whether Xe inhalation enhanced anxiety-like behavior in VPA-exposed rats. Non-invasive methods are described for estimating local cerebral blood flows (LCBF) and partition coefficients (L lambda) during inhalation of 35% stable xenon gas (Xes) in oxygen during CT scanning. 1998-2022 Mayo Foundation for Medical Education and Research (MFMER). All protocols and procedures were conducted in accordance with Moscow State Universitys Committee on Biomedical Research Ethics. Our data suggest that subanesthetic short-term exposures to Xe have beneficial effect on several behavioral modalities and deserves further investigation. The effectiveness of aripiprazole in the management of problem behaviour in people with intellectual disabilities, developmental disabilities and/or autistic spectrum disordera systematic review. 2015 Nov-Dec;60(6):71-4. Methods Seven neurocritical care patients were included in the study. Nature. It is plausible that such reaction is associated with negative emotions towards a stranger. https://doi.org/10.1007/s10803-012-1677-7. Data points represent 10 mins epochs. Erythropoietin (EPO) was measured at baseline, during, and after xenon inhalation. In the FS test we observed a tendency towards decreased time spent immobile and increased latency to first immobilization. Reynolds S, Millette A, Devine DP. We believe that further human studies with xenon inhalation should be conducted to explore possible early indicators for reduced tolerance of xenon by certain individuals. Call your doctor for medical advice about side effects. https://doi.org/10.1016/j.ridd.2013.12.004. Xenon acts like a really, really . Zhuang L, Yang T, Zhao H, Fidalgo AR, Vizcaychipi MP, Sanders RD, et al. Delayed effects of previous Xe inhalations on the behavior of normal rats in elevated O-maze on pnd 40. On pnd 13 VPA and Control groups were divided into VPA-Xe (N=14), VPA-air (N=14), Cont-Xe (N=11), Cont-air (N=13) groups of animals. Accessibility 2003;91:70917. Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. DCS/NIRS measurements of CBF and oxygenation from frontal lobes are compared with concurrent xenon-enhanced computed tomography (XeCT) in patients during induced blood pressure changes and carbon dioxide arterial partial pressure variation. Xenon-enhanced cerebral blood flow at 28% xenon provides uniquely safe access to quantitative, clinically useful cerebral blood flow information: a multicenter study. Anxious behaviors are also reported in the studies using VPA model of ASD in EPM [53, 55, 58, 61,62,63]. 2008;33:90112. https://doi.org/10.1038/sj.npp.1300518. 2015;80:4253. At the same time, Xe administration resulted in reduced exploratory motivation and/or emotionality evoked by novel conditions in OF and OM, and slightly decreased the risk-taking behavior in EPM. There was no difference in locomotor and grooming activity between groups. 7b). Xenon inhibits the plasma membrane Ca 2+ pump, 4 an action similar to that of volatile anesthetics, which may be responsible for an increase in neuronal Ca 2+ concentrations and altered excitability. Subsequently, a bypass . The most prominent feature of autism is social impairment. N 2 O, on the other hand, had no effect on the heart rate. Also, there was a tendency towards the decrease in time spent in the center of the arena (p=0.052) in Xe group vs. Control group. For a pair comparison we used either the Students T-test or the MannWhitney U-test and Fishers exact test for normally and abnormally distributed data, respectively. Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain. Deng J, Lei C, Chen Y, Fang Z, Yang Q, Zhang H, et al. Effects of acute Xe inhalation on the behavior of normal rats in elevated plus maze on pnd 25. 2008;2:4. https://doi.org/10.3389/neuro.04.004.2008. Manage cookies/Do not sell my data we use in the preference centre. Neurochem J. Of note, this is the first study in which a short-term exposure to Xe gas was used to evaluate such effects. 2015;20:11825. https://doi.org/10.1134/S0012496613030046. Careers. Effects of VPA treatment and acute Xe inhalation on the behavior of rats in elevated plus maze on pnd 25. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. PLoS ONE. Xenon (Xe) - Xenon is a rare, colorless, odorless, and chemically unreactive gas with atomic number 54 and represented with the symbol Xe in the Periodic Table. . Xenon impairs reconsolidation of fear memories in a rat model of Post-Traumatic Stress Disorder (PTSD). Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism. 2014;35:71125. A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate. Data were assessed for normality using the ShapiroWilks W to determine whether to use parametric or non-parametric statistical tests. Servadio M, Melancia F, Manduca A, Di Masi A, Schiavi S, Cartocci V, et al. Please enable it to take advantage of the complete set of features! Newschaffer CJ, Croen LA, Daniels J, Giarelli E, Grether JK, Levy SE, et al. Invest Radiol. Tell your doctor if you have a latex allergy before you start using this medicine. When inhaled, the effects are similar to inhaling nitrous oxide. Patz S, Hersman FW, Muradian I, Hrovat MI, Ruset IC, Ketel S, Jacobson F, Topulos GP, Hatabu H, Butler JP. Xenon (Xe) is a noble gas that has been used for the last several decades as an anesthetic during surgery. Topics: 2006;36:77993. In the current study we have conducted two series of experiments (series 1 and 2). . Lancet Neurol. These effects of xenon suggest that hyperventilation should be ensured in patients with evidence of reduced compliance or high ICP. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. 2013;43:145964. Xe administration didnt affect the behavior of healthy animals (p>0.70 vs. Cont group). Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, et al. Moreover, at pnd 68 a peak in the expression level of NMDA receptors occurs in rodents brain and this increase is presumably necessary for the developing brain because activation of glutamate system plays a substantial role in the morphogenesis and development of CNS plasticity [69]. xenon hexafluoride 10.4 Conditions to avoid no information available . All efforts were made to minimize the number of animals used. Also, frequency of grooming, rearing, head dips and approaches to outer edge of the open arms were recorded during the experiment. Behavior was monitored and registered with webcam for 3min. Mattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, et al. Abstract. Semax corrects brain dysfunction caused by prenatal introduction of valproic acid. 1998;396:324. https://doi.org/10.1038/24525. During steady state xenon inhalation (45 min), mean values of CBF and CGU do not differ from control values, and the relation of regional CBF to CGU is maintained, although reset at a higher level. CAS APD, VRG, AVM performed the experiments. Competitive inhibition at the glycine site of the N-methyl-d-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Our results suggest that Xe-exposed rats showed no sign of sedation as there was no decrease in horizontal locomotion and grooming activity in the OF test. These data suggest that even a short-term exposure to Xe can affect neurotransmission. The patient tolerated xenon inhalations well with no side effects, such as euphoria, lightheadedness, headache, nausea, or vomiting, during or after the procedure. These results suggest a modulatory effect of Xe inhalation on proclivity of risk-taking behavior and no effect on anxiety level of adolescent rats. Also, there was a significant reduction in head dips (p<0.001), center (<0.001) and open arm (p=0.002) entries as well as increased time spent in the closed arms of the maze (p=0.033) in VPA+Xe group in comparison with Cont group (Fig. Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, et al. It has been estimated that 40% of ASD patients have at least one anxiety disorder, with social anxiety being one of the most common among them (17%) [60]. https://doi.org/10.1016/j.pneurobio.2014.01.001. Volatile anaesthetics exert their effects at multiple sites throughout the central nervous system. While all but one subject tolerated xenon inhalation without ill effects, that individual did experience unpleasantly severe dysesthesias and a brief period of unresponsiveness. https://doi.org/10.1097/EJA.0b013e328357bfdd. and transmitted securely. This, in turn, stimulates the body to produce blood so . Clipboard, Search History, and several other advanced features are temporarily unavailable. In the current work, aggressive behavior as well as social anxiety of rats treated with VPA from pnd 6 to pnd 12 at the dose of 150mg/kg was significantly reduced by acute Xe administration. Time spent immobile (in seconds) (a) and latency to first immobilization (in seconds) (b) were measured within 5min observation. Handbook of assessment and diagnosis of autism spectrum disorder. This is a decision you and your doctor will make. https://doi.org/10.1097/ALN.0000000000000635. Along with its needed effects, a medicine may cause some unwanted effects. Six sessions of 4-min Xe inhalations have shown potency to reduce the severity of panic attacks and the severity of depressive disorders in patients with PD. Int J Dev Neurosci. OSTI.GOV Journal Article: Performance evaluation of xenon-133 inhalation rebreathing systems for regional blood flow measurements Journal Article: Performance evaluation of xenon-133 inhalation rebreathing systems for regional blood flow measurements A predefined secondary objective of the trial was to assess Xenon's cardioprotective effect with the extent of myocardial injury and the surrogate endpoint of difference in TnT increment post OHCA between groups of Xe inhalation and hypothermia and hypothermia only. Bessire B, Laboureyras E, Laulin JP, Simonnet G. Xenon prevents inflammation-induced delayed pain hypersensitivity in rats. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Would you like email updates of new search results? Time spent (in seconds) on the distal segments of open arms (a) and number of head dips (b) were measured within 5min observation. Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Terms and Conditions, According to most recent CDC report the overall prevalence of ASD in the US was 16.8 per 1000 (one in 59) children aged 8years (https://www.cdc.gov/ncbddd/autism/data.html). Disclaimer, National Library of Medicine In our study VPA treatment from pnd 6 to pnd 12 at a dose of 150mg/kg led to increased aggression and anxiety. B/G = blood-gas partition coefficient; Q = cardiac output, and. official website and that any information you provide is encrypted In support of low exploratory motivation theory it should be noted that previous studies reported no sedating effects of xenon after 30min treatment with 50% Xe/50% O2 gas mixture [41]. A single copy of these materials may be reprinted for noncommercial personal use only. 1, Moscow, 117997, Russia, Department of Biology, Lomonosov Moscow State University, Moscow, Russia, V. R. Gedzun,Iu. While all but one subject tolerated xenon inhalation without ill effects, that individual did experience unpleasantly severe dysesthesias and a brief period of unresponsiveness. Before the experiment an unfamiliar adult female rat was placed in the right chamber and tested animals dam was placed in the left goal arm of the maze. To measure anxiety-like behavior in rats we tested animals in the elevated plus maze (OpenScience Ltd, Russia) on pnd 25 as previously described [37]. Cattano D, Williamson P, Fukui K, Avidan M, Evers AS, Olney JW, et al. statement and | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on INHALATION. https://doi.org/10.1016/j.ijdevneu.2019.06.007. 2007 Dec;64(3):335-44. doi: 10.1016/j.ejrad.2007.08.008. 6a). There were no changes in the time spent in the starting arm, the amount of open arms entries and the number of head dips between groups (p>0.05). Suzuki T, Koyama H, Sugimoto M, Uchida I, Mashimo T. The diverse actions of volatile and gaseous anesthetics on human-cloned 5-hydroxytryptamine3receptors expressed in Xenopus oocytes. Data are presented as box and whiskers plot. Hobbs C, Thoresen M, Tucker A, Aquilina K, Chakkarapani E, Dingley J. Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Behavioral modulatory effects of Xe are probably related to its generalized action on excitatory/inhibitory balance within the CNS. Front Behav Neurosci. A time frame from pnd 6 to pnd 12 reflects sensitive period of functional development of the rats brain during which the processes of proliferation, synaptogenesis and myelination are ongoing. 2017;113:7181. 10). Anim Behav. A recent study reported a 2% frequency of co-occurrence of attention-deficit hyperactivity disorder in children with ASD [59], making this comorbid diagnosis rather uncommon in ASD. 2013;84:63743. On pnd 12 rat pups were acclimated to the gas exposure apparatus for 10min. Dobrovolsky, A.P., Gedzun, V.R., Bogin, V.I. Effects of acute Xe inhalation on the behavior of healthy intact rats in open field test on pnd 21. Krypton (along with xenon) is also used to fill incandescent lamps to reduce filament evaporation and allow higher operating temperatures. Prominent inhibitory effect of Xe on NMDA receptors makes this gas an attractive modality for studying pathological conditions involving these receptors. *p<0.05 and ***p<0.001 represent significant differences vs. Control group (Dunnetts multiple comparisons test), and $0.10p0.05 represent trend towards differences vs. Control group (Sidaks multiple comparisons test). trio who took drugs and described the effects it was having on them . Values represent latency (in seconds) to leave the closed arm of the maze. Postnatal stress induced by injection with valproate leads to developing emotional disorders along with molecular and cellular changes in the hippocampus and amygdala. Attenuatuation of myocardial injury by xenon . Kyoyama H, Hirata Y, Kikuchi S, Sakai K, Saito Y, Mikami S, Moriyama G, Yanagita H, Watanabe W, Otani K, Honda N, Uematsu K. Medicine (Baltimore). 2008;55:42936. Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism. **p<0.01 represent significant differences vs. Control group (MannWhitney U-test). On 3 occasions, participants breathed xenon (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) in a nonblinded design. We should note that in our study VPA group of animals has shown a tendency towards anxious behaviors, whereas VPA+Xe group has had a pronounced anxiety-like behavior in elevated plus maze. J Autism Dev Disord. It has mainly been researched as an anesthetic agent, though research has shown it could also be useful for neuroprotection. Carlson AP, Brown AM, Zager E, Uchino K, Marks MP, Robertson C, Sinson GP, Marmarou A, Yonas H. AJNR Am J Neuroradiol. 5). In these cases, your doctor may want to change the dose, or other precautions may be necessary. Inhalation in excessive concentrations can result in dizziness, nausea, vomiting, loss of consciousness, and death. 2). Xenon was consistently detected, albeit in trace amounts, up to 3 h after all three doses of xenon inhalation in blood and urine with variable results thereafter. The results of one-way ANOVA revealed a significant treatment effect on the number of head dips (F3, 48=5.172; p=0.004), number of center entries (F3, 48=6.176; p=0.001), number of open arm entries (F3, 48=4.361; p=0.008) and time spent in the closed arms (F3, 48=2.998; p=0.04). Epub 2007 Sep 24. In spite of its high cost, its lack of side effects, safe cardiovascular and organoprotective profile and effective neuroprotective role after hypoxic-ischemic injury (HI . After the successful completion of series 1, we assessed the effect of Xe inhalations on behavior in VPA-treated rats in series 2. Provided by the Springer Nature SharedIt content-sharing initiative. 9d). Post hoc analysis revealed a tendency towards increased climbing in VPA (p=0.096) and VPA+Xe (p=0.053) groups in comparison with Cont group of animals (Fig. Xenon caused variable levels of sedation and restlessness. At higher levels of CO, if the half of the haemoglobin is used in forming the COHb, death occurs. 1. Inhaling the mixture of oxygen and xenon produces a hormone which helps . 2014;115C:21045. This dosage is similar to that used clinically in Xenon-CT studies. There was no significant effect of treatment on the time spent with dam (F3, 48=0.326; p>0.80) and with unfamiliar adult female (F3, 48=0.825; p>0.40). Clin Child Fam Psychol Rev. FOIA Eur J Radiol. Hemodynamics were recorded during baseline conditions and during inhalation of 50% or 70% xenon, respectively. 2004;65:44352. The site is secure. This site needs JavaScript to work properly. 2019 Dec 1;127(6):1503-1510. doi: 10.1152/japplphysiol.00289.2019. Medically reviewed by Drugs.com. Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NP. Xenon Xe 133 is a radiopharmaceutical. Most of the studies of behavior in VPA model revealed some, but not all impairments of social interaction [55, 58, 65]. An identical system was used for air exposures except that only room air was supplied. There was no change in social behavior in healthy animals after Xe inhalation. J Neurosci Res. In comparison with other gaseous anesthetics it has beneficial properties such as rapid introduction into the brain, hemodynamic stability profile with little or no toxicity, and its lack of metabolizm [16]. Can J Anesth. Drug class: diagnostic radiopharmaceuticals, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. Check with your doctor or nurse immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. Over the first minute, 50% and 70% xenon caused a substantial reduction in total peripheral resistance (P < 0.05). Article Kohmura E, Grtner P, Holl K, Nemati N, Stoppe G, Lerch KD, Samii M. Rofo. Dr. Bogin is the co-founder and CEO of Nobilis Therapeutics, Inc., a company that is developing treatments for psychiatric disorders using noble gas xenon. This medicine is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine. Dias KA, Lawley JS, Gatterer H, Howden EJ, Sarma S, Cornwell WK 3rd, Hearon CM Jr, Samels M, Everding B, Liang AS, Hendrix M, Piper T, Thevis M, Bruick RK, Levine BD. A clinical evaluation of xenon enhancement for computed tomography. In the anesthesia plus xenon-group, rabbits were exposed to 1 MAC sevoflurane, 50% to 60% xenon and 30% oxygen. It is inside human body from 3-4 minutes, after which it leaves the lungs. Deb S, Farmah BK, Arshad E, Deb T, Roy M, Unwin GL. VPA group (Dunnetts multiple comparisons test). Children with ASD are more sensitive to pharmacological interventions and more likely to have adverse effects than children without ASD. Gould TD. Nelson SB, Valakh V. Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders. Anesteziol Reanimatol. If you notice any other effects, check with your healthcare professional. The test was performed under dim white light and familiar conditions (in the open field apparatus) on pnd 32. https://doi.org/10.1111/acer.12264. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Outflow factors: These factors are the determinant of uptake of inhaled anesthetics from the lungs. 2014;9:e106189. California Privacy Statement, Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels: comparison with isoflurane and ethanol. 2012;40:172430. Moreover, one-way ANOVA did not reveal any significant effects of treatment on the number of center entries (F3, 44=0.86; p=0.47) and grooming (F3, 44=0.66; p=0.58). 2015;20:813. The test consisted of placing two animals from the same group but from different litters and cages into an open field. https://doi.org/10.1016/j.nbd.2015.05.006. Cookies policy. In addition, Xe has shown ability to reduce behavioral despair of rats in FS. Holl K, Nemati N, Kohmura E, Gaab MR, Samii M. Acta Neurochir (Wien). Over the first minute, 50% and 70% xenon caused a substantial reduction in total peripheral resistance ( P < 0.05). We have shown that in healthy animals Xe exposure resulted in acute and delayed decrease of exploratory motivation, partial decrease in risk-taking and depressive-like behavior as well as improved sensorimotor integration during the negative geotaxis test. Thirdly, xenon inhalation was initiated immediately after LPS insulation. Ergaz Z, Weinstein-Fudim L, Ornoy A. 2013;16:91103. There was an increase in latency to leave the starting arm in Xe-exposed animals in comparison with control (p<0.01) (Fig. Bethesda, MD 20894, Web Policies Article Xenon caused variable levels of sedation and restlessness. Anesthesiology. The OM was conducted 5days after the last Xe inhalation, suggesting the prolonged effect of previous Xe exposures. To determine the chronic effects, eight subjects breathed 70% FiXe for . To assess any depression-like effects of VPA treatment, and potential antidepressant-like effect of Xe inhalation, rats were exposed to a forced swim test on pnd 35 in a transparent Plexiglas cylinder and the test was performed as previously described [37]. Based on these results we can conclude that 10min of 25% Xe inhalations is sufficient in modulating behavior of adolescent animals. Effects of VPA treatment and acute Xe inhalation on the behavior of rats in open field test on pnd 21. et al. Pre-exposure to Xe didnt affect the overall climbing activity but reduced such behavior to control levels in the second half of the experiment. 8600 Rockville Pike N=2123 rats/treatment. 2015;87:68498. Both increased [53, 56, 57] and unchanged [54, 58] locomotion in valproate-treated animals independent of dose and prenatal/postnatal administration of VPA have been reported. Accessibility The dead-ends of the goal arms were separated with wire mesh to form a corner large enough to hold a single adult rat. PMC ent of left ventricular pressure, cardiac output, and blood flow in the left anterior descending coronary artery (LAD) and circumflex coronary artery. Further preclinical models suggest potential clinical benefit of subanesthetic doses of Xe in indications such as traumatic brain injury, ischemic or hemorrhagic stroke, perinatal hypoxic-ischemic brain injury, coronary artery bypass graft surgery, organ protection during transplantation, chronic pain, addiction and post-traumatic stress disorder [18,19,20,21,22,23,24,25]. Sanders RD, Franks NP, Maze M. Xenon: no stranger to anaesthesia. Such complex behaviors involve both excitatory and inhibitory pathways which can be affected by endogenous and exogenous substances. In addition, an increased latency to leave the closed arm with no changes in other parameters in the OM suggests reduction of exploratory motivation in Xe-exposed rats. Although not all of these side effects may occur, if they do occur they may need medical attention. . The results of one-way ANOVA revealed a significant effect of treatment (F3, 48=9.473; p<0.001) on the latency to leave the starting area, with VPA group having larger latency in comparison with Cont (p=0.002) and Xe (p<0.001) group of animals. The Russian Bath Supra-molecular Detoxification Positively Stimulate Brain Activity, Increases Concentration and Psychical Performance Induce Deep Relaxing or Meditative State Reduces Fatigue, Anxiety, Depression and Irritability Under clinical studies to treat P.T.S.D. All authors read and approved the final manuscript. van Steensel FJA, Bgels SM, Perrin S. Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Persons who survive acute . Examinations of the effects of VPA on neurobehavioral development were carried out only in series 2. The https:// ensures that you are connecting to the The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Also, we have observed an increase in latency to leave starting area in social novelty test. The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment. The authors have shown that both nitrous oxide at 75 vol% and xenon at 50 vol% reduce ischemic neuronal death in the cortex by 70% and further decrease NMDA-induced Ca2+ influx by 30%. [53] 4.2 Most important symptoms and effects, both acute and delayed . *p<0.05 represent significant differences vs. Control group (MannWhitney U-test), $trend to significant difference 0.10p0.05. David HN, Haelewyn B, Rouillon C, Lecoq M, Chazalviel L, Apiou G, et al. Matson JL, editor. Number of total rearings (a) and number of sections crossed within first 2 and last 2min of observation (b) were measured within a 5-min observation. Sukhanova IA, Sebentsova EA, Khukhareva DD, Vysokikh MY, Bezuglov VV, Bobrov MY, et al. This study addresses an important yet under investigated effect of Xe administration on behavioral outcomes in healthy intact animals and in VPA-induced rodent model of autism. The observed impairments in both anesthesia groups when compared with the control group were similar to those observed in the first study. Latchaw et al. What it really does is stimulates low-level hypoxia (a condition wherein there is a deficiency in the amount of oxygen reaching the tissues). Neurotoxicol Teratol. Any history of brain injury and any active state involving entrapped air/gas within a body cavity with the potential to expand causing organ distension/compression (e.g., bowel obstruction, pneumothorax, or pneumocephalus). Sukhanova YA, Volodina MA, Sebentsova EA, Glazova NY, Manchenko DM, Inozemtseva LS, et al. It has been previously reported that VPA exposure on embryonic day 12.5 didnt alter the performance of rats in negative geotaxis test [51]. Inhalation: This gas is inert and is classified as a simple asphyxiate. Bantel C, Maze M, Trapp S. Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Correspondence to Eur J Anaesthesiol. 2012;7:e37020. A brighter light results with more blue color than conventional incandescent lamps. "Product Information. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Still, further studies broadening an understanding of anxiety-like behavior after Xe inhalation in VPA model of ASD may be warranted. The most prominent feature of autism is social impairment. Xenon can be used to assess all phases of ventilation. Conclusion There is still inconclusive evidence to support the administration of Xenon and argon inhalations on erythropoiesis and steroidogenesis and their positive effects on health. In the study of Kataoka et al. Xenon inhalation caused sedation incompatible with self-operation of a breathing apparatus, thus causing a potential life-threatening condition in the absence of an anesthesiologist. https://doi.org/10.1007/BF03016309. We have shown that acute treatment with subanesthetic dose of Xe in healthy animals leads to: improved sensorimotor integration in the negative geotaxis test; acute and delayed decrease of exploratory motivation; partial decrease in risk-taking and depressive-like behavior. 2009;110:98695. Also, other things may affect test results. Though, we have shown a trend towards increase in climbing activity in both VPA-exposed groups, with significant rise of struggling behavior in the second half of the testing in VPA group in comparison with Control group. The delivery (rate and concentration) both of Xe and atmospheric air (as needed to maintain 21% O2 concentration) was regulated by using flow meters (D6F-P0010A2, Omron, Japan). 2016;6:e902. Number of head dips (a), center entries (b), open arm entries (c) and time spent (in seconds) in the closed arms (D) were measured within 5min observation. Neuroscience. Br J Anaesth. Xenon is a member of the zero- valence elements that are called noble or inert gases. Moscow Univ Biol Sci Bull. Increasing evidence indicates that dysfunction of NMDA (N-methyl-d-aspartate) receptors (NMDARs) at excitatory synapses is associated with ASD [7]. The aim of this work was to assess the behavioral effects of acute inhalation of subanesthetic doses of Xe and to study the outcomes of Xe exposure in VPA-induced rodent model of autism. PubMed Inhalation of volumes of concentrated gases such as carbon monoxide, hydrogen sulfide, and xenon, even with medical supervision, may carry serious health risks. Its antagonistic effect on glutamate subtype of NMDA ( N -methyl- d -aspartate) receptors resulted in evaluation of this gas for treatment of CNS pathologies, including psychoemotional disorders. Download Table | Effect of xenon inhalation on regional CBF from publication: Effects of Xenon and Krypton on Regional Cerebral Blood Flow in the Rat | The effects of high inspired concentrations . The effects of postnatal VPA administration and Xe exposure on exploratory behavior and anxiety were studied in the EPM. Check with your doctor or nurse immediately if any of the following side effects occur while taking xenon xe-133: Incidence not known Cough difficulty with swallowing dizziness fast heartbeat hives itching puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue shortness of breath skin rash tightness in the chest Radiopharmaceuticals are radioactive agents, which may be used to find and treat certain diseases or to study the function of the body's organs. It is plausible that reduced climbing is a beneficial effect as it strategically helps to conserve energy in a stressful environment. https://doi.org/10.1134/s1819712418010154. https://doi.org/10.3103/S0096392515030074. 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