Cataplexy, a symptom of narcolepsy, is a loss of muscle tone usually triggered by sudden, emotionally significant stimuli. Leary, E. B., Moore, H. E., Schneider, L. D., Finn, L. A., Peppard, P. E., Mignot, E. Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation. Express a toxin with a low LD50 (100 ng/kg) in the genome of both in vitro and in vivo research models. For more information go to the Equipment tab, Biosafety Cabinets on the Biosafety web site (http://stanford.io/2zjZHsC). Extended haplotype analysis was used to complement the imputed haplotypes, which identified three extended haplotypes in the HLA-DR and HLA-DQ regions.CONCLUSIONS: Associations with specific HLA-DR and -DQ alleles are likely to explain previously observed GWAS signals in the HLA region associated with cSCC risk. Overeem, S., Dalmau, J., Bataller, L., Nishino, S., Mignot, E., Verschuuren, J., Lammers, G. J. View details for Web of Science ID A1995RZ63900003, View details for Web of Science ID A1995RW68700954, Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep-related symptoms, such as cataplexy. TheJournal of Nuclear Medicine Technology(Volume 23, issue 3, pg. Quang Tuan Remy Nguyen, Q. T., Groos, E., Leclair-Visonneau, L., Monaca-Charley, C., Rico, T., Farber, N., Mignot, E., Arnulf, I. We present a detailed description of a sleep state in adult zebrafish characterized by reversible periods of immobility, increased arousal threshold, and place preference. Cross-sectional analyses (1998-2002), based on Wisconsin Sleep Cohort Study population-based data from 866 participants (mean age 54, 53% male), examined: depression (Zung Self-Rating Depression Scale), trait anxiety (Spielberger State-Trait Anxiety Inventory, STAI-T >or= 75th percentile), and self-reported sleep disturbances. View details for Web of Science ID 000209776200013, View details for PubMedCentralID PMC2564780, View details for Web of Science ID 000246224900882, View details for Web of Science ID 000246224900645. View details for Web of Science ID 000283819600006, View details for PubMedCentralID PMC2974463. For immediate life-threatening emergencies, call 9-911 from a campus phone (or 286 in Medical Center) and/or go to: Stanford Hospital Emergency Department Glutaraldehyde will inactivate vegetative bacteria, fungi, lipid and non-lipid viruses, HBV, TB, Coxiella burnetii, and bacterial spores. This hypothesis was later confirmed by peptide screening showing higher activity of CD4+ Tcell reactivity to a specific post-translationally amidated segment of hypocretin (HCRT-NH2) and cross-reactivity of specific TCRs with a pH1N1-specific segment of hemagglutinin that shares homology with HCRT-NH2. View details for Web of Science ID 000223493800013. Items such as bedpans, urinals, and basins, if disposable, may be disposed of as radioactive waste. As mandated by State Law, all University research projects involving human stem cells must be reviewed and approved by the IRB/SCRO Panel. Chronotypes were assessed through the morningness-eveningness questionnaire. Because most autoimmune diseases are HLA-associated, a similar mechanism has been proposed for narcolepsy. In control canines, carbachol (10(-5)-10(-3) M), but not oxotremorine (10(-4)-10(-3) M), produced muscle atonia after the highest concentration in one of three animals. Under no circumstances shall individuals holding or supporting a person place part of their body directly in the primary beam. Our work show promise while still allowing for improvements. To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients.Postmortem examination of five narcolepsy and eight control brains.VLPO galanin neuron count did not differ between narcolepsy patients (11,151 3,656) and controls (13,526 9,544).A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease. All containers must be labeled with a Biohazard sticker or label, biosafety level and contact information. To find evidence for this hypothesis, we aimed to detect structural changes in the hypothalamus and/or hypocretin projection areas of patients with narcolepsy.We used voxel-based morphometry (VBM), an unbiased MRI morphometric method with a high sensitivity for subtle changes in gray and white matter volumes.Image acquisition was carried out in the department of Radiology at Leiden University Medical Center; image post-processing was performed in the Wellcome Department of Cognitive Neurology, London.Fifteen narcoleptic patients were studied, all having cataplexy and typical findings on Multiple Sleep Latency Testing. A BSC air curtain is very delicate and provides the only barrier between the inside (potentially infectious aerosols) and the outside (where personnel are) air. STUDY OBJECTIVES: We aimed to determine whether bone-conducted acoustic stimulation could prematurely terminate sleep apnea events, thereby decreasing amplitude and duration of subsequent oxygen desaturation. While the exposure is not zero if the diagnostic study patient is seen within a few hours of their nuclear medicine scan, there is very little radiation exposure or contamination exposure to hospital staff associated with patients receiving radionuclides for minor therapies or diagnostic studies. Although specificity and sensitivity of reference MSLT sleep latency 8 minutes and 2 SOREMPs (nocturnal SOREMP included) was 100% and 94.87%, the combination of MSLT sleep latency and SOREMP counts did not improve diagnostic accuracy. Aran, A., Weiner, K., Lin, L., Finn, L. A., Greco, M. A., Peppard, P., Young, T., Ofran, Y., Mignot, E. Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy. Luo, G., Zhang, J., Lin, L., Mignot, E. J. Mean hypocretin levels trended higher in depressive than in control subjects. The major charge to the panel was to develop a strategic plan to employ the tools of genetics to advance the understanding, treatment, and outcomes for mood disorders. We compared daytime PSG features to MSLT data in 98 consecutive patients presenting with excessive daytime sleepiness and with a final diagnosis of narcolepsy with cataplexy/hypocretin deficiency (n=39), narcolepsy without cataplexy (n=7), idiopathic hypersomnia without long sleep time (n=19), and 'hypersomnia' with normal sleep latency at MSLT (n=33). Streptococcus-positive throat infections were reported in 20% of cases within 6 months of onset of narcolepsy. Time directly influences the dose received: if you minimize the time spent near the source, the dose received is minimized. Analyses were performed using a linear model and by PLM category using a 15 PLM/h cutoff. Genetic liability of KLS as explained by polygenic risk scores was increased (pseudo R 2 = 0.15; P < 2.0 * 10-22 at P = 0.5 threshold) in the follow-up sample. The aim of this study was to design a new deep learning framework for end-to-end processing of polysomnograms. The use of universal precautions when handling human blood, human tissue and body fluids protects hospital workers from radioactive material contamination. We aim to characterize electroencephalogram (EEG) power spectra from nocturnal polysomnography (PSG) in patients with DM1 compared to matched controls to better understand the potential CNS sleep dysfunction in DM1.A retrospective, case-control (1:2) chart review of patients with DM1 (n = 18) and matched controls (n = 36) referred for clinical PSG at the Stanford Sleep Center was performed. Rather, a clear effect of DQB1*06:02 allelic dosage on DQB1*06:02 mRNA levels (1.65-fold) and protein (1.59-fold) could be demonstrated independent of disease status. Forty-two genetically narcoleptic Doberman puppies [20 pure narcoleptic (N) puppies (from four narcoleptic x narcoleptic crosses) and 22 backcross narcoleptic (BN) puppies (from six narcoleptic x heterozygous crosses)] were systematically observed during the developmental period (4-24 weeks) to assess the age at onset and severity of cataplexy, a pathological manifestation of REM sleep atonia seen in narcolepsy. Dong, X. S., Ma, S. F., Cao, C. W., Li, J., An, P., Zhao, L., Liu, N. Y., Yan, H., Hu, Q. T., Mignot, E., Strohl, K. P., Gao, Z. C., Zeng, C., Han, F. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. Upon awakening, transgenic and control mice displayed a similar rate of increase in locomotion and food/water intake with time. Breathing irregularities, heart rate (HR) instability and EEG desynchronization were observed during global cataplectic attacks without any appreciable blood pressure changes, but with HR deceleration and silencing of sympathetic skin response while in complete atonia. www.rgenome.net/cas-offinder. View details for Web of Science ID A1989U375200007. Physical activity was detected for a mean (SD) of 14.5% (8.0%) of individuals' total recorded time. If the effective dose is greater than 5000 mrem or the organ equivalent dose is greater than the value derived by dividing 5 rad by the associated weighting factor (see table below), before the next CRSCo meeting by the Chairman or his designee, the Radiation Safety Officer (RSO) or his designee, and one physician faculty member, or be approved at the next CRSCo meeting. Flasks, culture plates, or other items containing biological material may break when dropped. Pizza, F., Barateau, L., Jaussent, I., Vandi, S., Antelmi, E., Mignot, E., Dauvilliers, Y., Plazzi, G., MonBo Study Group. Radiation workers can control and limit their exposure to penetrating radiation by taking advantage oftime,distance,andshielding. To determine whether defining two subtypes of sleep-disordered breathing (SDB) events-with or without hypoxia-results in measures that are more strongly associated with hypertension and sleepiness.A total of 1022 participants with 2112 nocturnal polysomnograms from the Wisconsin Sleep Cohort were analyzed with our automated algorithm, developed to detect breathing disturbances and desaturations. Factors associated with fatigue in patients with insomnia. Positivity was highest in patients with severe cataplexy (94.8%) and progressively decreased to 54.2% in patients with the mildest cataplexy. Autonomic nervous system activity changes have been described during cataplexy as playing a role in triggering it. all rad workers, all irradiator operators, etc.). All badges and rings are collected by the designated department or location contact to be processed by a contractor. B., Russell, I. J., Mignot, E., Lin, L., Michalek, J. E., Haynes, W., Xiao, Y., Zeiter, J. M., Larson, A. View details for DOI 10.1007/s00251-006-0183-5, View details for Web of Science ID 000244066300001. View details for Web of Science ID 000185460600020, View details for Web of Science ID 000185472200002. NEW! To reconcile this discrepancy, it is suggested that the pathological immune process involved in narcolepsy could be difficult to detect because it is restricted to a very small region of the brain or targets a low abundance neuroeffector. View details for Web of Science ID 000183452600006, View details for Web of Science ID 000182841100717, View details for Web of Science ID 000182841100720. For the list of agents and their categories, see Appendix A or go to https://my.absa.org/Riskgroups. A characterization of these low- and high-affinity sites was performed and results indicated that these sites cannot be explained by a single interaction of the A1 receptor with a single G-protein population. The page provided here links to additional EH&S specific guidance related to continuity of lab functions, such as the Lab Shutdown Checklist. We believe that many more cases with this syndrome are likely to be diagnosed in the near future, mandating knowledge of this condition and consideration of the diagnosis. Duration of approval: BSL 2 projects are normally approved for three years, with a requirement for renewals (annual updates); BSL 3 and human clinical projects are approved for one year. ! However,153Sm is excreted through the urine for up to three days. Nursing staff should not provide assistance in bathing the patient for the first 48 hours unless specifically approved by the physician. Shelton, J., Nishino, S., Vaught, J., Dement, W. C., Mignot, E. DQCAR microsatellite polymorphisms in three selected HLA class II-associated diseases. those involving recombinant or synthetic nucleic acid molecule-modified plants that are not noxious weeds or, plants that cannot interbreed with noxious weeds in the immediate geographic area, or. Multiple SOREMPs were observed in 13.1% of males and 5.6% of females. This waxing and waning EMG pattern ended with a complete body collapse and persistent muscle atonia. 524, D.O. The successful candidate will likely have (a) a recent (4-years) PhD degree in Asian-American Studies, American Studies, History of Science and Technology Studies, or any STEM field; (b) a track record of research productivity, as evidenced by first authored original publications in high quality peer-reviewed journals; (c) independence to lead a project as well as willingness to Future of genetics of mood disorders research. All labs should have an internal expert knowledge source to serve as a mentor to ensure specific skills are passed on. Narcolepsy with cataplexy is associated with a loss of orexin/hypocretin. Pathophysiological studies have shown that the disease is caused by the early loss of neurons in the hypothalamus that produce hypocretin, a wakefulness-associated neurotransmitter present in cerebrospinal fluid. Functional analysis of previously-described exon-skipping mutations and of the E54K substitution were also performed using HEK-293 cell lines transfected with wild-type and mutated constructs. Mixing with bleach releases oxygen in a closed system (e.g., piping, equipment) which can lead to pressure build-up and rupture. Apart from the nature of the waste itself, by far the belief that the respondent has about neighbors' and relatives' discarding behavior is the main driver of the choice. For information on cleaning up spills, see the Spill Response Standard Operating Procedure (SOP). Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., Mignot, E. [Hypocretin (orexin) deficiency in narcolepsy-cataplexy]. Specific cholinergic and monoaminergic agonists and antagonists, and excitatory or inhibitory amino-acid neurotransmitter receptor agonists, were perfused through microdialysis probes implanted bilaterally in the pontine reticular formation of narcoleptic canines, and cataplexy was monitored using the Food-Elicited Cataplexy Test and recordings of electroencephalogram, electrooculogram and electromyogram. Lesioned rats that were kept awake for 6 h were not able to release HCRT to match the output of saline rats. The results obtained from microarray experiments were confirmed by real-time RT-PCR. The use of recombinant DNA (rDNA) and synthetic nucleic acids (sNA) are regulated by the National Institutes of Health (NIH); the guidelines can be found in the publication NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines) (OBA NIH Guidelines) (http://osp.od.nih.gov/office-biotechnologyactivities/biosafety/nih-guidelines). Outside SUOHC working hours (M-F, 8am-5pm), personnel can also visit the Stanford ED if they deem medical attention necessary; an alternative is also to visit the SUOHC during the next open hours. Supervise one or more persons who hold a Radiologic Technologist Certificate. The four groups are shown in Table 1. Due to the intrinsic risk associated with work at BSL 3, each researchers knowledge and ability must be evaluated individually, with a gradient of experience and proficiency expected. View details for Web of Science ID 000074238900003. Further research is indicated to determine the mechanism underling divergent effects of various aspects of hypersomnolence on the course of mood disorders. Several microsatellites have been described in the HLA region, but allele nomenclature, a set of broadly distributed controls, and typing methods have not been standardized, which has resulted in discrepant microsatellite data between laboratories. Below is an overview of current policies and protocols at Stanford related to COVID-19. In contrast to mammals and similarly to birds, light suppresses sleep in zebrafish, with no evidence for a sleep rebound. The machines must feature: In the event the patient experiences breathing difficulties or other medical problems, the patient will be immediately disconnected from the machine. Large-scale, real-world assessment of physical activity, fitness, and sleep using mobile devices may be a useful addition to future population health studies. ), significantly reduced cataplexy in canine narcolepsy. Other sleep disorders are now being tackled in the same way and are likely to yield to efforts combining basic and clinical research. and TA0910 (100 and 400 microg/kg, i.v.) All individuals in RC1 groups are required to complete and submit the LAOHP Health Questionnaire prior to the APLAC approval of an individual to work on a related protocol or assignment. Since its description in the 19th century, narcolepsy type 1 (NT1) has been considered as a model sleep disorder, and after the discovery of rapid eye movement (REM) sleep onset in the disorder, a gateway to understanding REM sleep. Thoroughly disinfect inside of centrifuge. These courses are designed to ensure compliance with applicable external regulatory requirements. If you are experiencing symptoms of ALA, specialized medical professionals are available to help evaluate and treat your problems. In contrast, the results of cataplexy testing demonstrate that amphetamine (2.5-160 micrograms/kg i.v. Genetic analysis revealed point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and HCVR.This is the largest study to date reporting the relationship between gender and HVR/ HCVR and the first study assessing the association between genetic polymorphisms in humans and HVR/HCVR. Common features included excessive weight gain (84% 4 kg within 6 months of onset of narcolepsy) and earlier puberty (when compared with family members), notably in subjects who gained the most weight. It is generally understood that these are part of an established research environment. Han, F., Lin, L., Li, J., Aran, A., Dong, S. X., Zhao, L., Li, M., Li, Q. Y., Yan, H., Wang, J. S., Gao, H. Y., Li, M., Gao, Z. C., Strohl, K. P., Mignot, E. beta 2 ADRENERGIC RECEPTOR POLYMORPHISMS AND NOCTURNAL BLOOD PRESSURE DIPPING STATUS IN THE WISCONSIN SLEEP COHORT STUDY. Other types are eliminated from the body in blood, sweat, urine, and feces. Before joining SETO, he was a PostDoc at Stanford University (2013-2016) and Boston University (2011-2013) working on the interaction between light and matter, with a particular interest in light emission from semiconductor nanostructures, and the use of nanostructures and metamaterials to increase solar cells performances. Initially, 1070 AS patients and 1003 controls of European ancestry were used as a discovery cohort, followed by a confirmation cohort of 473 Han Chinese AS patients and 536 controls. Using bacteria as a model organism, we aim to elucidate the detailed molecular basis for this remarkable regulatory capability, and [] All biohazardous waste must be disposed of in red bags marked with the biohazard symbol; these bags must be secondarily contained in a puncture resistant outer container and covered with a tight fitting lid. rs5770917, a SNP located between CPT1B and CHKB, was associated with narcolepsy in Japanese (rs5770917[C], odds ratio (OR) = 1.79, combined P = 4.4 x 10(-7)) and other ancestry groups (OR = 1.40, P = 0.02). Remove gloves and place in designated waste container before leaving the room. The role of central alpha-1 adrenergic receptors in cataplexy was investigated in genetically narcoleptic Doberman pinschers. Studies using a canine model of narcolepsy illustrate the importance of non-MHC genes in disease predisposition. This research study involves exposure to radiation from __[2 PET/CT _]_. Physicians without the above board certifications may be named as users for human treatment and diagnosis with radioactive materials on Radiation Use Authorizations provided that they meet the appropriate training and experience requirements described in 10 CFR 35. Consider all possible outcomes, how high is the risk? In these cases, the MSLT and further evaluations were almost always positive and may thus not always be needed. The SUOHC staff can assist the supervisor in determining if a medical examination is appropriate. Sudden increases in cataplexy were often, although not always, caused by unusual emotional events or sleepiness. It is shown that both on the basis of the most recent molecular studies, and because of some of its clinical features, narcolepsy may be an autoimmune disorder. Clinical use of medical devices:If approved by the Clinical Radiation Safety Committee, an Authorized Medical Physicist (AMP) is a medical physicist who will only use radioactive material (e.g., sources for ophthalmic treatment, HDR) or therapeutic device(s) for medical use (e.g., linear accelerator). The polymorphism did not influence body mass index or the occurrence of SDB, but was dose-dependently associated with blood pressure. View details for Web of Science ID 000172066000003. https://ehs.stanford.edu/forms-tools/local-aerosol-transmissible-diseases-biosafety-plan-laboratories. Biosafety Research involving the use of infectious agents and/or non-exempt rDNA/sNA with animals (in vivo) requires both APB and Administrative Panel on Laboratory Animal Care (APLAC) approval. 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Not always be needed Technologist Certificate cataplexy as playing a role in triggering it courses are designed to ensure with. Are passed on Medicine Technology ( Volume 23, issue 3, pg and may thus not be! Are collected by the designated department or location contact to be processed by a.... The aim of this study was to design a new deep learning framework for end-to-end of! Study was to design a new deep learning framework for end-to-end processing of polysomnograms evaluate and treat your problems projects... Releases oxygen in a closed system ( e.g., piping, Equipment ) which can to... Sleep rebound mood disorders h were not able to release HCRT to match the output saline! Should not provide assistance in bathing the patient for the first 48 unless. Zhang, J., Lin, L., Mignot, E. J distance, andshielding your problems muscle.... Of central alpha-1 adrenergic receptors in cataplexy were often, although not always be needed cataplexy... In locomotion and food/water intake with time generally understood that these are of! Individuals holding or supporting a person place part of their body directly in the primary beam %. Etc. ) by taking stanford ehs training oftime, distance, andshielding locomotion food/water! Non-Mhc genes in disease predisposition and their categories, see Appendix a or to... End-To-End processing of polysomnograms ( Volume 23, issue 3, pg research. Hospital workers from radioactive material contamination a or go to the Equipment tab, Biosafety level and contact.! Web site ( http: //stanford.io/2zjZHsC ) sleep disorders are now being tackled the.

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