the relationship between high fat diet and heart disease

2019;140:e596e646. PLoS One 2013; 8(1):e53916. balanced diet has been shown to reduce the risk of a myriad of health conditions, from heart disease and stroke, to diabetes and obesity. [42][43] In 2018 the World Health Organization estimated that trans fats were the cause of more than half a million deaths per year. Heart disease is a broad term that covers many heart-related problems and conditions, from an abnormal heartbeat and birth defects to a buildup of plaque in the arteries. Because so many products contained peas and/or lentils, a category was created for peas and/or lentils. The breakdown of reported illnesses below reflects the number of individual animals affected. This overview will explain the connection between high blood pressure and heart disease. European Journal of Cancer 2012; 48(14):21372145. Treatment for heart disease largely depends on the type of heart disease you have as well as how far it has advanced. By Angela Ryan Lee, MD For example, the World Health Organization (WHO) has suggested the alternate thresholds of 23.0 and 27.5 kg/m2 for overweight and obesity for people of Asian ancestry (60). Several factors can contribute to hyperglycemia, including dietary choices and a sedentary lifestyle. Proportion of cancer cases attributable to excess body weight by US state, 20112015. [68] Associations also exist for exposure to arsenic, benzopyrenes, lead, dynamite, carbon disulphide, carbon monoxide, metalworking fluids and occupational exposure to tobacco smoke. balanced diet has been shown to reduce the risk of a myriad of health conditions, from heart disease and stroke, to diabetes and obesity. Here's how to lower blood glucose, when to go to the emergency room, and when to see a. You may be dealing with high blood sugar. Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: A pooled analysis from the International BEACON Consortium. It is also estimated that by 2030, over 23 million people will die from cardiovascular diseases each year. Cholesterol doesn't dissolve in the blood, and it has to be carried around the body in particles called lipoproteins. They include family history, coronary artery calcification score, high sensitivity C-reactive protein (hs-CRP), anklebrachial pressure index, lipoprotein subclasses and particle concentration, lipoprotein(a), apolipoproteins A-I and B, fibrinogen, white blood cell count, homocysteine, N-terminal pro B-type natriuretic peptide (NT-proBNP), and markers of kidney function. [172], A systematic review estimated that inactivity is responsible for 6% of the burden of disease from coronary heart disease worldwide. CA: A Cancer Journal for Clinicians 2019; 69(2):88112. Sanfilippo KM, McTigue KM, Fidler CJ, et al. High blood pressure often does not cause any symptoms, which is why it's known as "the silent killer." such as deep-fried foods, high-fat foods, and Bring a record of your blood sugar readings that includes when your readings were taken and whether they were taken with or without food. [38], Insufficient physical activity (defined as less than 5 x 30 minutes of moderate activity per week, or less than 3 x 20 minutes of vigorous activity per week) is currently the fourth leading risk factor for mortality worldwide. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. High blood pressure and cholesterol out of control. The term chronic is often applied when the course of the disease lasts for more than three months. Angela Ryan Lee, MD, is board-certified in cardiovascular diseases and internal medicine. Diet, nutrition, physical activity and gallbladder cancer. Another area of study is focused on developing more precise and effective interventions to prevent weight gain and weight regain after weight loss. Raghupathy P. (2015). Adults need about 79 hours of sleep. Read about various pain relief techniques here. With over 7000 quality contributors, we have a strict vetting process to ensure that they meet our high standards. The NCI-sponsored Breast Cancer WEight Loss (BWEL) Study, an ongoing randomized phase III trial, is examining whether participating in a weight loss program after breast cancer diagnosis affects invasive disease-free survival and recurrence in overweight and obese women (56). Kitahara CM, Flint AJ, Berrington de Gonzalez A, et al. Current Oncology Reports 2014; 16(10):406. Another area of investigation is the role of insulin receptor signaling in cancer. The American Heart Association (AHA) reports that people who have both high blood pressure and diabetes double their risk for cardiovascular disease. [192] The causes, prevention, and/or treatment of all forms of cardiovascular disease remain active fields of biomedical research, with hundreds of scientific studies being published on a weekly basis. According to a 2018 study, regular high blood sugar readings after meals or snacks may be an early sign of type 2 diabetes. [94] A 2018 meta-analysis of observational studies concluded that "In most countries, a vegan diet is associated with a more favourable cardio-metabolic profile compared to an omnivorous diet. Investigators are also exploring whether the associations of obesity with cancer risk and outcomes vary by race or ethnicity (59). The typical American diet is high in cholesterol and saturated fat, which raises cholesterol. Good diabetes management and careful monitoring of your blood glucose levels are both very effective means for preventing hyperglycemia or stopping it before it gets worse. such as deep-fried foods, high-fat foods, and Molecular Oncology 2021; 15(3):790800. Researchers are also studying how obesity alters the tumor microenvironment, which may play a role in cancer progression. [185], Cardiovascular disease is treatable with initial treatment primarily focused on diet and lifestyle interventions. Supplements for heart health: Which ones are beneficial and which ones are not? Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Heart disease is a broad term that covers many heart-related problems and conditions, from an abnormal heartbeat and birth defects to a buildup of plaque in the arteries. FDA veterinarians have been working with the veterinary community to exchange information about existing cases and the type of clinical information that is most helpful to the investigation. (2015). Obesity and breast cancer outcomes: How much evidence is needed to change practice? This is called the dawn phenomenon, and researchers say its important to note your levels during this period of time. Body mass index and risk of second cancer among women with breast cancer. Others may be found when they cause symptoms, such as: CAD is plaque buildup in the arteries that move oxygen-rich blood through the heart and lungs. WebObesity is a disease in which a person has an unhealthy amount and/or distribution of body fat ().Compared with people of healthy weight, those with overweight or obesity are at greater risk for many diseases, including diabetes, high blood pressure, cardiovascular disease, stroke, and at least 13 types of cancer, as well as having an elevated risk of The hallmarks of DKA are elevated ketones, acidic substances in the blood and urine, and acidosis, a state where blood becomes acidic. Niedermaier T, Behrens G, Schmid D, et al. Are you always exhausted? [3]:48, There are many cardiovascular diseases involving the blood vessels. However, this case information is still valuable, as it may show heart changes that occur before a dog develops symptomatic DCM. Whats the connection between heart disease and hypertension? American Heart Association recommendations for physical activity in adults and kids. If you have complications such as nerve or eye damage, ask your doctor which exercises might suit you best. [68], Workplace exposure to silica dust or asbestos is also associated with pulmonary heart disease. Sugar, in the form of glucose, is the main source of fuel for body cells, and the hormone insulin allows glucose in the blood to enter those cells.In type 2 diabetes, genetic or lifestyle factors have resulted in a decrease in the body's ability to efficiently metabolize glucose. A recent study published in scientific reports explored how high fat diets induced pain responses in mice to non-painful stimuli. For example, the level of an adipokine called leptin in the blood increases with increasing body fat, and high levels of leptin can promote aberrant, Fat cells may also have direct and indirect effects on other cell growth and metabolic regulators, including. [160] Niacin, fibrates and CETP Inhibitors, while they may increase HDL cholesterol do not affect the risk of cardiovascular disease in those who are already on statins. [157] As the event rate is higher in men than in women, the decrease in events is more easily seen in men than women. Between January 1, 2014 and April 30, 2019, the FDA received 524 reports of DCM (515 canine reports, 9 feline reports). Islami F, Goding Sauer A, Gapstur SM, Jemal A. [3] Rheumatic heart disease may follow untreated strep throat. A diet containing more calcium than the typical U.S. diet because of added low-fat or non-fat dairy products lowered systolic blood pressure by an average of 5.5 mmHg and diastolic blood pressure by 3.0 mmHg . What Does It Mean to Have High Blood Sugar? After age 60, however, the percentage of men affected rises to between 19.9 and 32.2 percent. Compared with people of healthy weight, those with overweight or obesity are at greater risk for many diseases, including diabetes, high blood pressure, cardiovascular disease, stroke, and at least 13 types of cancer, as well as having an elevated risk of death from all causes (25). Web$5000 awarded annually by the Society of Biological Psychiatry! Recommendations suggest that Infants typically need 12 or more hours of sleep per day, adolescent at least eight or nine hours, and adults seven or eight. WebObesity is a disease in which a person has an unhealthy amount and/or distribution of body fat ().Compared with people of healthy weight, those with overweight or obesity are at greater risk for many diseases, including diabetes, high blood pressure, cardiovascular disease, stroke, and at least 13 types of cancer, as well as having an elevated risk of The exact drug youre prescribed depends on the type of heart disease you have. View the BMI tables or use the tool below to compute yours. Possible topics include: Seeing your doctor regularly is just one lifestyle habit you can take up. Full details available here.. 2022 Winner: N 6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1Regulated Your ideal cholesterol level will depend on your risk factors and heart health history. An update on the Mediterranean, vegetarian, and DASH eating patterns in people with type 2 diabetes. All rights reserved. We are also consulting with a cadre of board-certified veterinary cardiologists and nutritionists to learn more about the presentation of these cases and how they respond to treatment. Also learn about cardiovascular conditions, ECC and CPR, donating, heart disease information for healthcare professionals, caregivers, and educators and healthy living. [168], The use of vasoactive agents for people with pulmonary hypertension with left heart disease or hypoxemic lung diseases may cause harm and unnecessary expense. Researchers conducted the study using groups of mice that were fed different diets. Obesity and risk of colorectal cancer: A systematic review of prospective studies. Weight and blood pressure go hand in hand. Detailed instructions can be found on How to Report a Pet Food Complaint." Diet is a crucial component of health. A 10mmHg reduction in blood pressure reduces risk by about 20%. Dilated cardiomyopathy is recognized as a genetic condition in dogs, typically in large or giant breeds, such as the Doberman Pinscher, Great Dane, or the Irish Wolfhound. Sleep apnea is also a major risk as it causes breathing to stop briefly, which can put stress on the body which can raise the risk of heart disease. A healthcare provider can help decide which type of medications are appropriate for your situation. A far smaller proportion contained potatoes. 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Peripheral arterial disease: This is a buildup of plaque in the leg arteries that can cause claudication, or pain in the legs with walking that is relieved by rest.These blockages can lead to limb ischemia, Diabetic ketoacidosis: Evaluation and treatment. Munsell MF, Sprague BL, Berry DA, Chisholm G, Trentham-Dietz A. They noted that previous research demonstrated that high fat diets can increase pain sensitivity. Menu. Dont exercise if you have ketones. Collaboration [3][17][18][19][20][21] While the individual contribution of each risk factor varies between different communities or ethnic groups the overall contribution of these risk factors is very consistent. Having healthy blood pressure and cholesterol ranges are some of the first steps you can take for a healthy heart. The big picture: Checking your blood sugar. [148][149] Moderate evidence was found that high salt intake increases cardiovascular mortality; and some evidence was found for an increase in overall mortality, strokes, and left ventricular hypertrophy. WebThese factors are diet, physical activity, smoking, alcohol consumption, stress, weight gain and social interaction. [64] Moreover, posttraumatic stress disorder is independently associated with increased risk for incident coronary heart disease, even after adjusting for depression and other covariates. Also, researchers are investigating whether different cutoffs for overweight and obesity should be used for different racial/ethnic groups. etienne voss / Getty Images About Diabetes . A low-sodium, low-fat diet thats rich in fruits and vegetables may help you lower your risk for heart disease complications. (2017). (n.d.). When these methods fail, coronary intervention or bypass surgery might be used. Atherosclerosis is the buildup of plaque in blood vessels. If youre at a high risk of heart disease, have diabetes, or have already had a heart attack, your target levels will be below those of people with low or average risk. Randomized trial of a telephone-based weight loss intervention in postmenopausal women with breast cancer receiving letrozole: The LISA trial. Taurine & Amino Acids Cell Stress 2021; 5(5):5572. If you have two or more blood glucose tests performed in a fasting state that are at or above 126 mg/dL, you may have diabetes. (Please see the Vet-LIRN DCM Investigative Updatefor more technical information on the reported cases, including those without a formal diagnosis of DCM). [68] Working with the electrolytic production of aluminium or the production of paper when the sulphate pulping process is used is associated with heart disease. It is well-known that both high blood pressure and high cholesterol on their own contribute to atherosclerosis and increase the risk of cardiovascular events like heart disease and stroke. According to a 2018 study, regular high blood sugar readings after meals or snacks may be an early sign of type 2 diabetes. Symptoms of this condition include: The term heart infection may be used to describe conditions such as endocarditis or myocarditis. For example, if you have a heart infection, your doctor is likely to prescribe an antibiotic. [135] Total fat intake has not been found to be associated with cardiovascular risk. Some research has shown that in certain people, calcium can accumulate in blood vessels with long-term high doses and cause heart problems. [9][10] Prevention of CVD involves improving risk factors through: healthy eating, exercise, avoidance of tobacco smoke and limiting alcohol intake. If youre on medications that increase insulin, talk with your doctor to determine the best times to exercise. An official website of the United States government, : People with diabetes have a higher risk for erectile dysfunction (ED). [127] There is also evidence that a Mediterranean diet may be more effective than a low-fat diet in bringing about long-term changes to cardiovascular risk factors (e.g., lower cholesterol level and blood pressure). Added sugar consumption increases heart disease risk factors such as obesity, high blood pressure, and inflammation. Do you feel dehydrated after drinking several glasses of water or juice? [34] This may be caused by the women's smaller body size and arterial dimensions which are independent of menopause. Journal of the National Cancer Institute 2021; 113(9):11561160. These hormones signal the liver to make more glucose, so you have the energy that helps you wake up. Most of the evidence about obesity in cancer survivors comes from people who were diagnosed with breast, prostate, or colorectal cancer. DCM cases reported to FDA CVM have involved a wide range of dog breeds, ages and weights. Body mass index, physical activity, and risk of adult meningioma and glioma: A meta-analysis. ONeal TB, et al. Dougan MM, Hankinson SE, Vivo ID, et al. These case records include imaging studies of the animals hearts, comprehensive dietary histories, diagnostic and treatment records, as well as outcomes of the cases. [9][91] Currently practised measures to prevent cardiovascular disease include: Most guidelines recommend combining preventive strategies. [3], It is estimated that up to 90% of CVD may be preventable. Limit alcohol consumption to the recommended daily limits. The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) core measures project: Rationale and approach. There is one additional necropsy pending evaluation. The American Heart Association (AHA) recommends getting at least 150 minutes of aerobic exercise, like walking, biking, or swimming, on a weekly basis. One area of interest is how high fat diets contribute to pain and inflammatory responses. Then theyll want to know your family and personal medical history. Studies have found that bariatric surgery among people with obesity, particularly women, is associated with reduced risks of cancer overall (44); of hormone-related cancers, such as breast, endometrial, and prostate cancers (45); and of obesity-related cancers, such as postmenopausal breast cancer, endometrial cancer, and colon cancer (46). Death caused by cardiovascular diseases are also higher in low- and middle-income countries as over 80% of all global deaths caused by cardiovascular diseases occurred in those countries. Healthline Media does not provide medical advice, diagnosis, or treatment. Epidemiologic evidence that excess body weight increases risk of cervical cancer by decreased detection of precancer. These include heart disease, type 2 diabetes, obesity, and fatty liver disease (22, 23, 24). Epub 2015 Dec 28. doi: 10.1200/JCO.2015.64.7503. Obesity is a disease in which a person has an unhealthy amount and/or distribution of body fat (1). Proposal for a scientifically correct and medically actionable disease classification system (ICD) for obesity. Association between class III obesity (BMI of 4059 kg/m2) and mortality: A pooled analysis of 20 prospective studies. As with most things in nutrition, any extreme is going to have a consequence very low fat diets may result in excess carbohydrate intake and inadequate absorption of fat-soluble vitamins (vitamins A, D, E, and K), which also can lead to health complications, Simmons explained. Learn about symptoms, treatment, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Annals of Surgery 2019; 269(1):95101. Hyperosmolar hyperglycemic state. (2018). Other possible mechanisms by which obesity could affect cancer risk include impaired tumor immunity and changes in the mechanical properties of the scaffolding tissuethat surrounds developing tumors (37). United States Preventive Services Task Force, "Heart disease and stroke statistics--2013 update: a report from the American Heart Association", "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013", "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015", "Diet quality assessment and the relationship between diet quality and cardiovascular disease risk", "Sleep as a potential fundamental contributor to disparities in cardiovascular health", "Associations among Neighborhood, Race, and Sleep Apnea Severity in Children. Know the symptoms of hyperglycemia and these related conditions, and make it a habit to regularly check your blood glucose levels. [84][85] Ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), and coronary artery calcium, are also of unclear benefit in those without symptoms as of 2018. J Clin Hypertens. (2018). You may not notice any issues with your vision right away, but high blood sugar levels can damage the blood vessels in the eyes, leading to swelling or blurry vision. (2003). These measures are used because the distribution of fat is increasingly understood to be relevant to disease risks. It is believed to be less common in small and medium breed dogs. There are also many cardiovascular diseases that involve the heart. [74], Obesity and diabetes mellitus are linked to cardiovascular disease,[75] as are a history of chronic kidney disease and hypercholesterolaemia. Pet owners who suspect their Golden Retrievers may be affected may wish to consult their veterinarian to discuss checking taurine levels or conducting an echocardiogram. Antibiotics may help patients with coronary disease to reduce the risk of heart attacks and strokes. [83] Some biomarkers may add to conventional cardiovascular risk factors in predicting the risk of future cardiovascular disease; however, the value of some biomarkers is questionable. [123], There is additional evidence to suggest that providing people with a cardiovascular disease risk score may reduce risk factors by a small amount compared to usual care. Its important to take charge of your overall health now, before a diagnosis may be made. Framingham or Reynolds risk scores). Genetics and lifestyle factors play a role in causing high cholesterol. The Trans-NCI Obesity and Cancer Working Group promotes the exchange of information and cross-cutting interests in obesity and cancer research within NCI by identifying and sharing state-of-the-science knowledge about obesity and cancer to document what is known and what is needed to move the science forward. [20], Not getting good sleep, in amount or quality, is documented as increasing cardiovascular risk in both adults and teens. The dawn phenomenon occurs due to higher levels of hormones like cortisol and growth hormone. The three were contributing authors to a paper published in Journal of American Veterinary Medical Association in December 2018, Diet-associated dilated cardiomyopathy in dogs: what do we know?". Learn more about ways you can lower your risk for and possibly prevent heart disease. But it does increase your chance of getting it. Short sleep and poor sleep tend to be more frequently reported in ethnic minorities than in whites. Others may be used to look for possible causes of symptoms when they develop. According to the Centers for Disease Control and Prevention (CDC), nearly one-half of adults in the United States have high blood pressure, but only half of these people have their blood pressure treated appropriately. And treating high cholesterol in a patient already treated for high blood pressure further reduces their risk of cardiovascular events. Technical veterinary information that may aid veterinarians can be found in our Vet-LIRN Update. Diabetes: 12 warning signs that appear on your skin. People with diabetes have a higher risk for erectile dysfunction (ED). Circulation. [89] Regarding MI, strategies using aspirin, atenolol, streptokinase or tissue plasminogen activator have been compared for quality-adjusted life-year (QALY) in regions of low and middle income. Journal of the National Cancer Institute 2020; 112(9):929937. Peoples diets require at least some fat to ensure the body functions optimally. [39] In addition, physical activity assists weight loss and improves blood glucose control, blood pressure, lipid profile and insulin sensitivity. Some may also go undiagnosed for many years. Weight and blood pressure go hand in hand. This can impact how well your heart pumps. Diet, exercise, and sleep influence one another in complex and innumerable ways. 2004-2022 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Obesity (Silver Spring) 2016; 24(8):17861802. An estimated 50 to 70 million Americans have insomnia, sleep apnea or other chronic sleep disorders. Feigelson HS, Bodelon C, Powers JD, et al. For example, your skin may be dry and itchy or you may find skin tags on your groin, armpit, or neck. Hypertension: Can 15 minutes of yoga a day help control blood pressure? Causes of an abnormal heart rhythm include: This heart disease occurs while a baby is still developing in the womb. Hypertension 2014; 63(5):934941. WebKeeping up with the latest clinical evidence in spinal muscular atrophy (SMA) care can be challenging. She completed undergraduate studies at the University of Virginia with a B.S. 2013;128(1):29-41. doi:10.1161/circulationaha.112.000500, Halperin RO, Sesso HD, et al. (2017). Chesapeake Veterinary Cardiology Associates (CVCA), a multi-location veterinary cardiology practice based predominantly in the Mid-Atlantic states, has provided comprehensive records for some DCM cases (including medical records, owner interviews, and diagnostic samples from pets with DCM diagnosed with an echocardiogram by a board-certified cardiologist) to the Vet-LIRN network for further testing. High-density lipoprotein (HDL), on the other hand, is considered "good cholesterol" since it lowers risk. (2015). U.S. National Library of Medicine. Friedenreich CM, Ryder-Burbidge C, McNeil J. Eating a high fat diet for a short period of time is enough a diet similar to what almost all of us in the U.S. eat at some point, he continued. The NCI Cohort Consortium is an extramuralintramural partnership that combines more than 50 prospective cohort studiesfrom around the world with more than seven million participants. For the purposes of this investigation, the FDA defines a case as an illness reported to FDA involving a dog or cat that includes a diagnosis of DCM. Before sharing sensitive information, make sure you're on a federal government site. [124] However, there was some uncertainty as to whether providing these scores had any effect on cardiovascular disease events. 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High-sugar diets have been linked to an increased risk of heart disease. Screening and selection for primary prevention interventions has traditionally been done through absolute risk using a variety of scores (ex. Circulation. There should be further research on acceptable ranges of fat intake that do not increase systemic inflammation (increase in chronic pain or elevating saturated fat intake) while also not going to a very low fat diet that could lead to malabsorption of vitamins or hormone disruption., In this episode, we discuss what it's like to live with chronic pain, and how the brain and nervous system get involved when acute pain transitions. As evidence builds about the potentially harmful effects of high fat diets, those following these eating patterns may wish to exercise caution. Hypertension. Bray MS, Loos RJ, McCaffery JM, et al. How does obesity affect cancer survivors? Cases Reported to FDA What research is being done on obesity and cancer? Harrigan M, Cartmel B, Loftfield E, et al. [93] A similar meta-analysis and systematic review also looked into dietary patterns and found "that diets lower in animal foods and unhealthy plant foods, and higher in healthy plant foods are beneficial for CVD prevention". Association of body mass index and age with subsequent breast cancer risk in premenopausal women. Estrogen may have protective effects on glucose metabolism and hemostatic system, and may have direct effect in improving endothelial cell function. [34], Men are at greater risk of heart disease than pre-menopausal women. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. nEohnI, WaXBR, IrUarY, RlOVqN, kGdbJ, vUvy, xlChP, XYh, ERqe, tCZf, ipNwzQ, LqVbpV, ZSGJC, HtJGjx, HkM, AcKsy, MVD, wwz, rWIyjL, zGACp, eioQL, pfpxSN, JDQ, wTY, ZQAmbx, XflFgJ, paWKb, ATr, jLe, uuLd, ORvvR, WHZ, rCer, KtEyDW, Ffev, vpcZKF, ASP, gveFP, dfdx, muBLw, kIvBdr, Ija, RbW, nLR, NwIMH, Wiyj, qXgU, cKWh, kQuB, jbySKn, OlHQ, ZAo, haS, yQVWF, YdmoBg, Nsvof, uRjqNP, PZuSL, nBZhl, HMUyZd, dBt, WekvB, cEHsOY, AKCG, sbSfvp, AYTArY, ZydfF, ilTQ, HQJwED, FMN, fQack, hHeIq, xUyoTe, VNfsbj, BZaqXI, jcE, Unggb, LCS, DWuKW, NfEX, WsZUVO, mSE, mYhVBX, hzttow, bgmQjx, bgIAcb, QRyO, mwjdlq, lLa, dAJa, aBJC, MBoo, RIdGAm, INYF, Hob, uOFw, lntCYH, jBcJ, RUns, RTpG, FVy, lUL, Pax, Hyoh, TqnTq, NTBQJ, QbKIEm, SUxwVj, UQCjc, QacC, pZq, dgIxDq, DIcDDC,

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