pharmacodynamic synergism. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Minor/Significance Unknown. hydrochlorothiazide, verteporfin. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)sulfasalazine increases and indapamide decreases serum potassium. nafcillin, indapamide. Monitor Closely (3)digoxin will increase the level or effect of hydrochlorothiazide by basic (cationic) drug competition for renal tubular clearance. indapamide and artemether/lumefantrine both increase QTc interval. xipamide increases effects of indapamide by pharmacodynamic synergism. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Monitor Closely (1)norepinephrine and indapamide both decrease serum potassium. Monitor Closely (1)succinylcholine increases and indapamide decreases serum potassium. Use Caution/Monitor. Consult your doctor for more details.Check your blood pressure and pulse (heart rate) regularly while taking this medication. Effect of interaction is not clear, use caution. Contraindicated. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. valsartan increases and indapamide decreases serum potassium. calcitriol topical, indapamide. Increased phototoxicity. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. hydrochlorothiazide will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. NOTE: The Food Additives Status List is provided only as a quick look-up on the use limitations for a food additive. Minor/Significance Unknown. Avoid or Use Alternate Drug.Minor (1)indapamide, trimethoprim. Use Caution/Monitor. sorafenib and indapamide both increase QTc interval. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of fenoprofen by acidic (anionic) drug competition for renal tubular clearance. Contraindicated (1)indapamide and octreotide (Antidote) both increase QTc interval. sulindac, captopril. indapamide decreases levels of magnesium oxide by increasing renal clearance. Minor (1)hydrochlorothiazide increases levels of ampicillin by decreasing renal clearance. Please confirm that you would like to log out of Medscape. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Monitor Closely (1)apomorphine and indapamide both increase QTc interval. Consider decreasing dosage of antihypertensive agent. Use Caution/Monitor. Hypokalemia. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. prednisolone, hydrochlorothiazide. Use Caution/Monitor. Hypokalemia increases digoxin effects. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Minor (1)indapamide decreases effects of nateglinide by pharmacodynamic antagonism. hydrochlorothiazide, indacaterol, inhaled. Use Caution/Monitor. hydrochlorothiazide will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension. Minor/Significance Unknown. pirbuterol and hydrochlorothiazide both decrease serum potassium. Most May increase the hypokalemic effects of thiazide diuretics. Minor (1)hydrochlorothiazide will increase the level or effect of fenbufen by acidic (anionic) drug competition for renal tubular clearance. Minor (1)indapamide will increase the level or effect of fenbufen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Minor/Significance Unknown. This Food Additives Status List, formerly called Appendix A of the Investigations Operations Manual (IOM), organizes additives found in many parts of 21 CFR into one alphabetized list. Monitor Closely (1)losartan increases and hydrochlorothiazide decreases serum potassium. Modify Therapy/Monitor Closely. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Thiazide-like diuretics may also enhance the nephrotoxic effects of ACE inhibitors. Food Additives & Petitions, Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Food Ingredient and Packaging inventories, Indirect Additives Used in Food Contact Substances, Effective Food Contact Substance (FCS) Notifications, Component or coating for fruits & vegetables, Essential oil and/or oleoresin (solvent free), Substances under the Food Additives Amendment added directly to feed, Substance used in conjunction with flavors, Sanitizing agent for food processing equipment, Spices, other natural seasonings & flavorings, Veterinary drug, which may leave residue in edible tissues of animals or in edible animal products. Minor/Significance Unknown. Each drug may increase the photosensitizing effect of the other. etodolac increases and indapamide decreases serum potassium. dopexamine and hydrochlorothiazide both decrease serum potassium. Potential additive hypercalcemia. Comment: Thiazide diuretics may increase serum calcium by decreasing urinary calcium excretion. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. DRUG INTERACTIONS: See also How To Use section.Drug interactions may change how your medications work or increase your risk for serious side effects. Possible additive hyponatremia. Minor/Significance Unknown. Risk of hypokalemia, especially with strong glucocorticoid activity. Risk of hypokalemia, especially with strong glucocorticoid activity. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Either increases effects of the other by QTc interval. Modify Therapy/Monitor Closely. hydrochlorothiazide will increase the level or effect of aspirin/citric acid/sodium bicarbonate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Effect of interaction is not clear, use caution. Make sure lab personnel and all your doctors know you use this drug. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Additives included are those specified in the regulations promulgated under the FD&C Act, under Sections 401 (Food Standards), and 409 (Food Additives). Minor/Significance Unknown. 2.5 mg PO qDay initially; may increase to 5 mg qDay, 1.25 mg PO qAM initially; may increase at 4-week intervals up to 5 mg qAM, May use normal saline for volume replacement, May use dopamine or norepinephrine to treat hypotension, If dysrhythmia due to decreased K+ or Mg+ suspected replace aggressively, Discontinue treatment if no symptoms after 6hr. Monitor Closely (1)losartan increases and indapamide decreases serum potassium. Hypokalemia. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. penbutolol increases and hydrochlorothiazide decreases serum potassium. Minor (1)indapamide decreases effects of acarbose by pharmacodynamic antagonism. epinephrine and indapamide both decrease serum potassium. Either increases levels of the other by decreasing renal clearance. Be aware that as a result of the Food Quality Protection Act of 1996 and Antimicrobial Regulation Technical Corrections Act of 1998, EPA now has jurisdiction over sanitizing solutions applied to permanent or semi-permanent food contact surfaces, other than food packaging. Use Caution/Monitor. Minor (1)indapamide decreases effects of insulin NPH by pharmacodynamic antagonism. Hypokalemia. Effect of interaction is not clear, use caution. Additives: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z. Use alternatives if available. Minor (1)prednisolone, hydrochlorothiazide. Use Caution/Monitor. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor. parecoxib increases and indapamide decreases serum potassium. dicloxacillin, hydrochlorothiazide. Compare formulary status to other drugs in the same class. commonly, these are "non-preferred" brand drugs or specialty Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Potential additive hypercalcemia. Monitor Closely (1)norepinephrine and hydrochlorothiazide both decrease serum potassium. Either increases effects of the other by pharmacodynamic synergism. Potential additive hypercalcemia. Minor/Significance Unknown. Monitor Closely (1)tolmetin increases and indapamide decreases serum potassium. indapamide increases toxicity of lithium by decreasing elimination. Effect of interaction is not clear, use caution. Thiazide dosage >50 mg/day may increase blood glucose. Monitor Closely (1)hydrochlorothiazide, bretylium. If you log out, you will be required to enter your username and password the next time you visit. hydrochlorothiazide, trimethoprim. Minor/Significance Unknown. Fluoride salts typically have distinctive bitter tastes, and are odorless. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Minor (1)octacosanol increases effects of indapamide by pharmacodynamic synergism. Minor/Significance Unknown. indapamide will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. diflunisal increases and hydrochlorothiazide decreases serum potassium. Hypokalemia. Use Caution/Monitor. cyclopenthiazide will increase the level or effect of indapamide by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Controlled studies in pregnant women show no evidence of fetal risk. indapamide decreases effects of sitagliptin by pharmacodynamic antagonism. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of mefenamic acid by acidic (anionic) drug competition for renal tubular clearance. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. Increased myelosuppressive effects. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Possible additive hyponatremia. Use Caution/Monitor. indapamide decreases effects of glipizide by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)fenoprofen increases and indapamide decreases serum potassium. Avoid or Use Alternate Drug. Most GRAS substances have no quantitative restrictions as to use, although their use must conform to good manufacturing practices. diazoxide, indapamide. Modify Therapy/Monitor Closely. Increased risk of orthostatic hypotension. hydrochlorothiazide will increase the level or effect of aspirin by acidic (anionic) drug competition for renal tubular clearance. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of celecoxib by acidic (anionic) drug competition for renal tubular clearance. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).This medication may interfere with certain lab tests (including parathyroid function), possibly causing false test results. Use Caution/Monitor. Beta-agonists may acutely worsen ECG changes and/or hypokalemia resulting from non-potassium-sparing diuretics. Minor/Significance Unknown. Risk of hyponatremia. hydrochlorothiazide decreases levels of magnesium chloride by increasing renal clearance. If you need help in determining the acceptability of a flavoring after consulting 21 CFR 172.515, contact CFSAN Office of Food Additive Safety (HFS-200) at. Contraindicated.Monitor Closely (1)sotalol increases and indapamide decreases serum potassium. Avoid or Use Alternate Drug. First-Time Generic Approvals: Focalin, Valtrex, Hydrodiuril, Female Stress Urinary Incontinence: An Evidence-Based, Case Study Approach, Medscape Cardiologist Wealth & Debt Report 2021. cyclopenthiazide and hydrochlorothiazide both decrease serum potassium. Either increases effects of the other by pharmacodynamic synergism. reishi increases effects of hydrochlorothiazide by pharmacodynamic synergism. Monitor Closely (1)ezogabine, indapamide. Minor/Significance Unknown. chlorthalidone and indapamide both decrease serum potassium. dofetilide and indapamide both increase QTc interval. Minor/Significance Unknown. pivmecillinam, indapamide. Monitor Closely (1)cornsilk increases effects of indapamide by pharmacodynamic synergism. Monitor Closely (1)indapamide and pasireotide both increase QTc interval. ibuprofen increases and hydrochlorothiazide decreases serum potassium. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Monitor Closely (1)oxaprozin increases and hydrochlorothiazide decreases serum potassium. Each drug may increase the photosensitizing effect of the other. Contraindicated (1)maprotiline and indapamide both increase QTc interval. Other (see comment). Hypokalemia.indapamide, terbutaline. Use Caution/Monitor. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. This drug is available at the lowest co-pay. provider for the most current information. potassium citrate increases and hydrochlorothiazide decreases serum potassium. Mechanism: pharmacodynamic synergism. To view formulary information first create a list of plans. Monitor Closely (1)ketorolac intranasal increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Minor/Significance Unknown.hydrochlorothiazide decreases effects of chlorpropamide by pharmacodynamic antagonism. Monitor glycemic control especially when initiating, discontinuing, or increasing thiazide diuretic dose. Coadministration of hydrochlorothiazide with cyclosporine may increase the risk of hypermagnesemia, hyperuricemia, and possible nephrotoxicity.Serious - Use Alternative (1)cyclosporine, hydrochlorothiazide. Electrocardiographic changes and/or hypokalemia associated with non?potassium-sparing diuretics may worsen with concomitant beta-agonists, particularly if recommended dose is exceeded. Thiazide dosage >50 mg/day may increase blood glucose. Hypokalemia. Monitor Closely (1)xipamide increases effects of hydrochlorothiazide by pharmacodynamic synergism. Minor (1)birch increases effects of indapamide by pharmacodynamic synergism. Use Caution/Monitor. Risk of alkalosis, hypercalcemia. Effect of interaction is not clear, use caution. Monitor Closely (1)maitake increases effects of indapamide by pharmacodynamic synergism. This website also contains material copyrighted by 3rd parties. Use Caution/Monitor. albuterol and hydrochlorothiazide both decrease serum potassium. Minor/Significance Unknown. Increased risk of systemic hyponatremia. Use Caution/Monitor. Monitor Closely (1)meclofenamate increases and hydrochlorothiazide decreases serum potassium. A: Generally acceptable. indapamide will increase the level or effect of diflunisal by acidic (anionic) drug competition for renal tubular clearance. PRECAUTIONS: Before taking hydrochlorothiazide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. meloxicam increases and indapamide decreases serum potassium. Mechanism: pharmacodynamic synergism. Hypokalemia. Use Caution/Monitor. The recipient will receive more details and instructions to access this offer. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)potassium chloride increases and hydrochlorothiazide decreases serum potassium. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Use Caution/Monitor. indapamide and lapatinib both increase QTc interval. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. chlorothiazide will increase the level or effect of indapamide by acidic (anionic) drug competition for renal tubular clearance. informational and educational purposes only. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Hypokalemia. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Thiazide dosage >50 mg/day may increase blood glucose. Monitor Closely (1)aspirin/citric acid/sodium bicarbonate increases and hydrochlorothiazide decreases serum potassium. Minor (1)hydrochlorothiazide increases levels of sulfisoxazole by unspecified interaction mechanism. Use Caution/Monitor. Minor/Significance Unknown. Minor (1)hydrochlorothiazide will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Risk of alkalosis, hypercalcemia. fentanyl transdermal decreases effects of indapamide by Other (see comment). Effect of interaction is not clear, use caution. indapamide and pentamidine both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. terbutaline, indapamide. indapamide decreases effects of insulin degludec by Other (see comment). Minor/Significance Unknown. This information does not assure that this product is safe, effective, or appropriate for you. aminolevulinic acid oral, indapamide. Monitor Closely (1)aceclofenac increases and hydrochlorothiazide decreases serum potassium. Mechanism: pharmacodynamic synergism. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.If you have diabetes, hydrochlorothiazide may affect your blood sugar. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. ketorolac intranasal increases and indapamide decreases serum potassium. Minor (1)treprostinil increases effects of hydrochlorothiazide by pharmacodynamic synergism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. indapamide, trimethoprim. Minor/Significance Unknown. Canada residents can call a provincial poison control center. Effect of interaction is not clear, use caution. An official website of the United States government, : Either increases effects of the other by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Monitor Closely (1)oxaprozin increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown. naproxen increases and hydrochlorothiazide decreases serum potassium. Use Caution/Monitor. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. Monitor glycemic control especially when initiating, discontinuing, or increasing thiazide diuretic dose. Use Caution/Monitor. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. hydrochlorothiazide decreases effects of exenatide injectable solution by pharmacodynamic antagonism. Minor/Significance Unknown. pharmacodynamic antagonism. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of diclofenac by acidic (anionic) drug competition for renal tubular clearance. indapamide and risperidone both increase QTc interval. Minor (1)shepherd's purse, hydrochlorothiazide. Minor/Significance Unknown. Monitor Closely (1)empagliflozin, indapamide. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Both drugs lower blood pressure. Contraindicated. Monitor Closely (1)hydrochlorothiazide and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. 3Water (Aqua), Sodium C14-16 Olefin Sulfonate, Cocamidopropyl Betaine, Hydrolyzed Pearl, Macrocystis Pyrifera (Kelp) Extract, Polyquaternium-22, PEG-7 Amodimethicone, Linoleamidopropyl Pg-Dimonium Chloride Phosphate, Polyquaternium-39, Sodium Hydrolyzed Potato Starch Dodecenylsuccinate, PEG-150 Pentaerythrityl Effect of interaction is not clear, use caution. Hypokalemia. Use Caution/Monitor. fenoprofen increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Additive photosensitizing effects. Comment: Fentanyl can reduce the efficacy of diuretics by inducing antidiuretic hormone release. Serious - Use Alternative (1)indapamide and posaconazole both increase QTc interval. Contraindicated. Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist.This medication may make you more sensitive to the sun. budesonide, hydrochlorothiazide. Gastrointestinal Endoscopy publishes original, peer-reviewed articles on endoscopic procedures used in the study, diagnosis, and treatment of digestive diseases. buprenorphine, long-acting injection decreases effects of indapamide by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)indapamide and deflazacort both decrease serum potassium. Comment: Theoretically, shepherd's purse may interfere with BP control. diflunisal increases and indapamide decreases serum potassium. Use Caution/Monitor. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Minor/Significance Unknown. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)indapamide and bedaquiline both increase QTc interval. Monitor Closely (1)nebivolol increases and indapamide decreases serum potassium. Mechanism: pharmacodynamic synergism. Minor (1)indapamide decreases effects of insulin regular human by pharmacodynamic antagonism. Minor (1)hydrochlorothiazide decreases effects of tolazamide by pharmacodynamic antagonism. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval. hydrocortisone, indapamide. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose. dichlorphenamide and indapamide both decrease serum potassium. Minor (1)hydrochlorothiazide increases levels of piperacillin by decreasing renal clearance. Minor (1)indapamide decreases effects of insulin lispro by pharmacodynamic antagonism. chlorothiazide and indapamide both decrease serum potassium. Monitor Closely (1)cyclopenthiazide and indapamide both decrease serum potassium. indapamide and voriconazole both increase QTc interval. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of diflunisal by acidic (anionic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely. indapamide decreases effects of glyburide by pharmacodynamic antagonism. Minor (2)hydrochlorothiazide will increase the level or effect of metformin by basic (cationic) drug competition for renal tubular clearance. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. Effect of interaction is not clear, use caution. For example, in the case of boiler water additives or other minor ingredients, processing aids, or indirect additives, FDA has not objected, in certain cases, to the substitution of ammonium, calcium, magnesium, potassium, or sodium salts for each other when only one is listed in a regulation. Contraindicated (1)epinephrine racemic and indapamide both increase QTc interval. buprenorphine, long-acting injection decreases effects of hydrochlorothiazide by pharmacodynamic antagonism. This is a fact sheet intended for health professionals. indapamide, sulfamethoxazole. Comment: May lead to hypercalcemia (theoretical). Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. indapamide will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide decreases effects of glipizide by pharmacodynamic antagonism. Minor (1)indapamide will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. indapamide and levoketoconazole both increase QTc interval. Risk of hypotension. sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol, triamcinolone acetonide injectable suspension, Sulfonamide or sulfonamide-derivative drugs, like indapamide, can cause an idiosyncratic reaction resulting in acute angle-closure glaucoma and elevated intraocular pressure with or without a noticeable acute myopic shift and/or choroidal effusions; symptoms may include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation, Untreated, angle-closure glaucoma may result in permanent visual field loss; primary treatment is to discontinue indapamide as rapidly as possible; prompt medical or surgical treatments may need to be considered if intraocular pressure remains uncontrolled, Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy, Severe cases of hyponatremia, accompanied by hypokalemia reported with recommended doses primarily in elderly females; appears to be dose-related. tizanidine increases effects of hydrochlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown. isoproterenol and hydrochlorothiazide both decrease serum potassium. Monitor glycemic control especially when initiating, discontinuing, or increasing thiazide diuretic dose. Monitor blood pressure and renal function. diclofenac increases and hydrochlorothiazide decreases serum potassium. Monitor Closely (1)arformoterol and hydrochlorothiazide both decrease serum potassium. Minor (1)hydrochlorothiazide increases levels of calcium citrate by decreasing renal clearance. Minor/Significance Unknown. Minor/Significance Unknown. Contraindicated.Monitor Closely (1)epinephrine and indapamide both decrease serum potassium. indapamide and ranolazine both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor.Minor (1)salmeterol, indapamide. Minor/Significance Unknown. hydrochlorothiazide will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. Minor/Significance Unknown. digoxin will increase the level or effect of hydrochlorothiazide by basic (cationic) drug competition for renal tubular clearance. Mechanism: pharmacodynamic synergism. hydrochlorothiazide decreases effects of insulin glulisine by pharmacodynamic antagonism. indapamide will increase the level or effect of tolfenamic acid by acidic (anionic) drug competition for renal tubular clearance. ECG should be monitored closely. Contraindicated. hydrochlorothiazide will increase the level or effect of diclofenac by acidic (anionic) drug competition for renal tubular clearance. Comment: Diuretics may cause hyperglycemia and glycosuria in patients with diabetes mellitus, possibly by diuretic-induced hpokalemia. Contraindicated. Risk of hypotension. Monitor Closely (1)arformoterol and indapamide both decrease serum potassium. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Modify Therapy/Monitor Closely. hydrochlorothiazide increases levels of dofetilide by decreasing renal clearance. Minor/Significance Unknown. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Most May enhance hypokalemic effect of thiazide diuretics. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Modify Therapy/Monitor Closely. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. dobutamine, hydrochlorothiazide. Avoid or Use Alternate Drug. Mechanism: pharmacodynamic synergism. epoprostenol increases effects of hydrochlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypokalemic effects. Mechanism: pharmacodynamic synergism. Take your next dose at the regular time. bumetanide and hydrochlorothiazide both decrease serum potassium. indapamide will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide, shark cartilage. Comment: Diuretics may cause hyperglycemia and glycosuria in patients with diabetes mellitus, possibly by diuretic-induced hpokalemia. maitake increases effects of indapamide by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Hypokalemia. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (1)torsemide and hydrochlorothiazide both decrease serum potassium. Modify Therapy/Monitor Closely. hydrochlorothiazide will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. Anuria. Monitor Closely (1)pivmecillinam, indapamide. Use Caution/Monitor. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. Minor (1)forskolin increases effects of indapamide by pharmacodynamic synergism. Minor (1)goldenrod increases effects of hydrochlorothiazide by pharmacodynamic synergism. Adding plans allows you to compare formulary status to other drugs in the same class. Use Caution/Monitor. Here are the omissions: Please send corrections or additions to the list to Harold Woodall, FDA/CFSAN Office of Food Additive Safety (HFS-206), 5100 Paint Branch Parkway, College Park, Maryland 20740 or e-mail them to harold.woodall@fda.hhs.gov. Use Caution/Monitor. Applies only to oral form of both agents. Minor (1)indapamide decreases effects of metformin by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Monitor Closely (1)sulindac increases and hydrochlorothiazide decreases serum potassium. Use Caution/Monitor. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Mechanism: pharmacodynamic synergism. Monitor Closely (1)bendroflumethiazide and hydrochlorothiazide both decrease serum potassium. Risk of hypokalemia, especially with strong glucocorticoid activity. Also refer to the Food Ingredient and Packaging inventories in the Foods section of the FDA web siteto review several FDA databases of additive categories. indapamide will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Either increases levels of the other by decreasing renal clearance. Monitor Closely (1)temocillin, indapamide. haloperidol and indapamide both increase QTc interval. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. arformoterol, indapamide. Use Caution/Monitor. ketoprofen increases and hydrochlorothiazide decreases serum potassium. Monitor Closely (1)hydrochlorothiazide increases toxicity of lily of the valley by Other (see comment). Avoid or Use Alternate Drug. Risk of hyponatremia. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of indomethacin by acidic (anionic) drug competition for renal tubular clearance. Hypokalemia increases digoxin effects. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Substances for which prior sanction has been granted by FDA for specific uses. Both drugs lower blood pressure. Use Caution/Monitor. indapamide, indacaterol, inhaled. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)hydrochlorothiazide decreases effects of exenatide injectable solution by pharmacodynamic antagonism. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Minor (1)cortisone, indapamide. Effect of interaction is not clear, use caution. Risk of hypokalemia, especially with strong glucocorticoid activity. esmolol increases and hydrochlorothiazide decreases serum potassium. Mechanism: unspecified interaction mechanism. Mechanism: pharmacodynamic synergism. Minor (1)indapamide decreases effects of pioglitazone by pharmacodynamic antagonism. potassium chloride increases and hydrochlorothiazide decreases serum potassium. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. indapamide and nilotinib both increase QTc interval. Avoid or Use Alternate Drug. hydrochlorothiazide decreases effects of insulin regular human by pharmacodynamic antagonism. . Comment: Additive hypotensive effects may be seen when MAOI's are combined with antihypertensives. Serious - Use Alternative (1)indapamide, aminolevulinic acid topical. Monitor blood pressure and renal function. Other (see comment). shepherd's purse, hydrochlorothiazide. Use Caution/Monitor. promethazine and indapamide both increase QTc interval. macimorelin and indapamide both increase QTc interval. Monitor glycemic control especially when initiating, discontinuing, or increasing thiazide diuretic dose. Substances in this category are by definition, under Sec. Minor/Significance Unknown. Serious - Use Alternative (1)iloperidone and indapamide both increase QTc interval. succinylcholine increases and indapamide decreases serum potassium. arformoterol and hydrochlorothiazide both decrease serum potassium. Monitor Closely (1)drospirenone increases and hydrochlorothiazide decreases serum potassium. Contraindicated. Minor (1)hydrochlorothiazide decreases effects of glipizide by pharmacodynamic antagonism. hydrochlorothiazide will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. indapamide increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. 25-100 mg PO once daily or twiced daily; not to exceed 200 mg/day, 25 mg PO qDay or twice daily; not to exceed 200 mg/day, <6 months: 1-3 mg/kg/day PO divided q12hr; not to exceed 37.5 mg/day, 6 months-2 years: 1-2 mg/kg/day PO in single daily dose or divided twice daily; not to exceed 37.5 mg/day, 2-12 years: 1-3 mg/kg/day; not to exceed 3 mg/kg/day (100 mg/day), 6 months-2 years: 1-3 mg/kg/day PO in single daily dose or divided twice daily; not to exceed 37.5 mg/day, Increased hypotension and side effects in elderly, Potential for electrolyte imbalance in elderly; monitor serum electrolytes, 12.5-25 mg/day PO; titrated in increments of 12.5 mg/day, Increased electrolyte disturbances are seen with dosages >50 mg/day. Modify Therapy/Monitor Closely. Increased phototoxicity. lornoxicam increases and indapamide decreases serum potassium. trifluoperazine and indapamide both increase QTc interval. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. acemetacin increases and hydrochlorothiazide decreases serum potassium. Comment: Juniper may potentiate or interfere with diuretic therapy. Contraindicated. Minor/Significance Unknown. Glyphosate is an aminophosphonic analogue of the natural amino acid glycine and, like all amino acids, exists in different ionic states depending on pH.Both the phosphonic acid and carboxylic acid moieties can be ionised and the amine group can be protonated and the substance exists as a series of zwitterions.Glyphosate is soluble in water to 12 g/L at room temperature. Mechanism: pharmacodynamic synergism. Monitor Closely (1)terbutaline and hydrochlorothiazide both decrease serum potassium. Modify Therapy/Monitor Closely. Thiazide dosage >50 mg/day may increase blood glucose. Monitor Closely (1)hydrochlorothiazide will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Contraindicated. Effect of interaction is not clear, use caution. Monitor Closely (1)spironolactone increases and hydrochlorothiazide decreases serum potassium. Serious - Use Alternative (1)indapamide, tretinoin. Risk of hypokalemia, especially with strong glucocorticoid activity. Limit alcoholic beverages. Use Caution/Monitor. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. indapamide decreases effects of tolazamide by pharmacodynamic antagonism. indapamide and methadone both increase QTc interval. Modify Therapy/Monitor Closely. Minor/Significance Unknown. forskolin increases effects of hydrochlorothiazide by pharmacodynamic synergism. May decrease responsiveness to norepinephrine but not enough to preclude effectiveness of the pressor agent therapeutic use. indapamide decreases effects of insulin degludec/insulin aspart by Other (see comment). Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Consult your doctor before breast-feeding. noni juice increases and indapamide decreases serum potassium. cornsilk increases effects of hydrochlorothiazide by pharmacodynamic synergism. Avoid or Use Alternate Drug. US residents can call their local poison control center at 1-800-222-1222. Effect of interaction is not clear, use caution. May enhance hyperglycemic effects of diazoxide. Use Caution/Monitor. hydrochlorothiazide and deflazacort both decrease serum potassium. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of aceclofenac by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide decreases levels of folic acid by increasing renal clearance. CUSTOMER SERVICE: Change of address (except Japan): 14700 Citicorp Drive, Bldg. Use Caution/Monitor.Minor (1)hydrochlorothiazide increases levels of penicillin G aqueous by decreasing renal clearance. Mechanism: pharmacodynamic synergism. temocillin, indapamide. Use Caution/Monitor. Hypokalemia. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes. Alcohol or marijuana (cannabis) can make you more dizzy. hydrochlorothiazide increases levels of penicillin G aqueous by decreasing renal clearance. Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Risk of hypokalemia, especially with strong glucocorticoid activity. Hypokalemia. Risk of hypokalemia, especially with strong glucocorticoid activity. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)hydrochlorothiazide, porfimer. Risk of hypokalemia, especially with strong glucocorticoid activity. Use Caution/Monitor. Thiazide dosage >50 mg/day may increase blood glucose. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor (1)indapamide decreases effects of vildagliptin by pharmacodynamic antagonism. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. Monitor Closely (1)dofetilide will increase the level or effect of hydrochlorothiazide by basic (cationic) drug competition for renal tubular clearance. Mechanism: pharmacodynamic synergism. Use Caution/Monitor.digoxin increases and hydrochlorothiazide decreases serum potassium. Modify Therapy/Monitor Closely. Minor (1)cosyntropin, hydrochlorothiazide. Risk of hypokalemia, especially with strong glucocorticoid activity. Avoid or Use Alternate Drug. Contraindicated. Comment: Diuretics may cause hyperglycemia and glycosuria in patients with diabetes mellitus, possibly by diuretic-induced hpokalemia. Minor/Significance Unknown. commonly, these are generic drugs. Use Caution/Monitor. cefamandole will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide decreases levels of magnesium oxide by increasing renal clearance. Comment: Caution is advised in the coadministration of indacaterol neohaler with non-potassium-sparing diuretics. Use Caution/Monitor. epinephrine and hydrochlorothiazide both decrease serum potassium. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor.Minor (2)terbutaline, hydrochlorothiazide. Contraindicated. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)drospirenone increases and indapamide decreases serum potassium. terbutaline, hydrochlorothiazide. celecoxib increases and hydrochlorothiazide decreases serum potassium. celecoxib increases and indapamide decreases serum potassium. Thiazide dosage >50 mg/day may increase blood glucose. noni juice increases and hydrochlorothiazide decreases serum potassium. Thiazide dosage >50 mg/day may increase blood glucose. Minor (1)hydrochlorothiazide will increase the level or effect of memantine by basic (cationic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. Contraindicated (1)prochlorperazine and indapamide both increase QTc interval. epinephrine racemic and indapamide both increase QTc interval. Minor (1)treprostinil increases effects of indapamide by pharmacodynamic synergism. Other (see comment). Effect of interaction is not clear, use caution. Minor (1)ceftibuten will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. Risk of alkalosis, hypercalcemia. methyclothiazide will increase the level or effect of indapamide by acidic (anionic) drug competition for renal tubular clearance. agrimony increases effects of hydrochlorothiazide by pharmacodynamic synergism. Abnormal electrolyte levels (e.g., sodium, calcium, and magnesium) Spironolactone (Aldactone) can lower sodium, calcium, and magnesium levels in your blood. Use with caution. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Go to the, 0.2 percent in lye-peeling solution to assist in the lye peeling of fruits and vegetables - 173.315, Rosin, wood, pentaerythritol ester of maleic anhydride - CTG, REG, GMP, Ctg on fresh citrus fruit - 172.210. indapamide decreases effects of tolbutamide by pharmacodynamic antagonism. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. indapamide and bedaquiline both increase QTc interval. Minor/Significance Unknown. Monitor Closely (1)valsartan increases and indapamide decreases serum potassium. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. The .gov means its official.Federal government websites often end in .gov or .mil. indapamide will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended. Effect of interaction is not clear, use caution. Most people with high blood pressure do not feel sick. Nitrofurantoin is an antibacterial medication used to treat urinary tract infections, but it is not as effective for kidney infections. Monitor Closely (1)indapamide and carbenoxolone both decrease serum potassium. epinephrine racemic, indapamide. Comment: Caution is advised in the coadministration of indacaterol neohaler with non-potassium-sparing diuretics. Contraindicated. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. Keep taking this medication even if you feel well. Either increases effects of the other by pharmacodynamic synergism. naproxen increases and indapamide decreases serum potassium. Use Caution/Monitor. Monitor Closely (1)indapamide increases toxicity of lily of the valley by Other (see comment). Minor/Significance Unknown. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Increased phototoxicity. nafcillin, hydrochlorothiazide. Effect of interaction is not clear, use caution. piroxicam increases and indapamide decreases serum potassium. Minor/Significance Unknown. Monitor Closely (1)penbutolol increases and indapamide decreases serum potassium. Use Caution/Monitor.Minor (1)hydrochlorothiazide, carbenoxolone. Monitor Closely (1)indomethacin increases and indapamide decreases serum potassium. tadalafil increases effects of indapamide by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. harm to an unborn baby if used during pregnancy. Minor (1)colestipol decreases levels of indapamide by inhibition of GI absorption. Baking soda is the common name for sodium bicarbonate, an ingredient that got its start 4 million years ago when salt lakes around the world evaporated and formed trona deposits. Minor/Significance Unknown. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes. indapamide decreases effects of saxagliptin by pharmacodynamic antagonism. By clicking send, you acknowledge that you have permission to email the recipient with this information. Mechanism: pharmacodynamic synergism. aspirin/citric acid/sodium bicarbonate increases and hydrochlorothiazide decreases serum potassium. Monitor glycemic control especially when initiating, discontinuing, or increasing thiazide diuretic dose. Minor/Significance Unknown. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. lurasidone increases effects of hydrochlorothiazide by Other (see comment). Increased risk of nephrotoxicity. Minor (1)hydrochlorothiazide increases levels of penicillin VK by decreasing renal clearance. Minor/Significance Unknown. Minor/Significance Unknown. Coadministration of empagliflozin with diuretics results in increased urine volume and frequency of voids, which might enhance the potential for volume depletion. Hypokalemia. Minor/Significance Unknown. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias. Use Caution/Monitor. It works by causing you to make more urine. Monitor Closely (1)amifostine, indapamide. Serious - Use Alternative (1)indapamide, methyl aminolevulinate. Monitor Closely (1)candesartan increases and indapamide decreases serum potassium. hydrochlorothiazide decreases levels of magnesium sulfate by increasing renal clearance. hydrochlorothiazide will increase the level or effect of procainamide by basic (cationic) drug competition for renal tubular clearance. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)indapamide decreases effects of exenatide injectable suspension by pharmacodynamic antagonism. aceclofenac increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Hypokalemia. Mechanism: pharmacodynamic synergism. Comment: Fentanyl can reduce the efficacy of diuretics by inducing antidiuretic hormone release. Modify Therapy/Monitor Closely. pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Use Caution/Monitor.indapamide increases effects of digoxin by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor. erythromycin base and indapamide both increase QTc interval. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)indapamide and metolazone both decrease serum potassium. This information is not individual medical advice and does not substitute for the advice of your health care professional. hydrochlorothiazide decreases levels of L-methylfolate by increasing renal clearance. indapamide and gentamicin both decrease serum potassium. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)hydrochlorothiazide increases toxicity of squill by Other (see comment). Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. prescription products. Minor (1)hydrochlorothiazide increases effects of minoxidil by pharmacodynamic synergism. indapamide decreases effects of rosiglitazone by pharmacodynamic antagonism. Monitor Closely (2)indapamide and alfuzosin both increase QTc interval. Use Caution/Monitor. Minor (1)indapamide decreases levels of magnesium hydroxide by increasing renal clearance. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)indapamide and ranolazine both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. Thiazide dosage >50 mg/day may increase blood glucose. Contraindicated. hydrochlorothiazide will increase the level or effect of cefprozil by acidic (anionic) drug competition for renal tubular clearance. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)indapamide and tropisetron both increase QTc interval. quetiapine, indapamide. Comment: Thiazide diuretics decrease renal calcium excretion and may increase risk of hypercalcemia in patients taking toremifene. methylprednisolone, indapamide. Minor/Significance Unknown. ibutilide and indapamide both increase QTc interval. Minor/Significance Unknown. Hypokalemia. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Additive hypokalemic effects. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. hydrochlorothiazide will increase the level or effect of meclofenamate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Modify Therapy/Monitor Closely. hydrochlorothiazide will increase the level or effect of metolazone by acidic (anionic) drug competition for renal tubular clearance. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. eprosartan increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Other (see comment). Monitor Closely (1)terbutaline and indapamide both decrease serum potassium. Long-term exposure can result in thickening of the skin, darker skin, abdominal pain, diarrhea, heart disease, Contraindicated. Minor/Significance Unknown. Answer your medical questions on prescription drugs, vitamins and Over the Counter medications. Minor/Significance Unknown. metoprolol increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. 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