Time to second PSA progression was longer in group A than in group B (median 19.3 months versus 15.2 months; HR=0.66; 95%CI 0.45 to 0.97; p=0.036). These may include endocrinologists, orthopedic surgeons, primary care physicians, or other specialists who focus on bone heath. Barr was limited on Wednesday, as was DeMarcus Lawrence and Jayron Kearse, with Kearse stating he'd continue fighting through what ails him (shoulder) to try and remain available for the Cowboys during the most critical stretch of their regular season. He has not played in a game since tearing his ACL this past January. After finishing the 2021 season with a career-high five sacks and nearly getting half of that entire year's production in just one game, the needle is pointing due north for Armstrong and a defense that has shown it can shut down some of the best arm talent in the NFL - sacking Burrow a total of six times on the afternoon. He remains one of the NFL's best running backs and has surely ensured that no regression has come as a result of his injury. The Titans traded A.J. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Dak can now set his sights on Aikman (165), possibly this year but will have some work to do to catch Romo (247). Stay up-to-date on the latest news, schedules, scores, standings, stats and more. To date, there is little prospective randomized data evaluating PET as a staging study for untreated prostate cancer, mHSPC or CRPC.161 While studies are being completed to generate data for FDA registration based on safety and performance, what will ultimately determine the role of these PET agents will be trials demonstrating improved patient outcomes as a direct result of earlier intensification of systemic therapies, MDT, and/or prediction of responses to specific therapies. J Clin Oncol 2018; Tangen CM, Faulkner JR, Crawford ED et al: Ten-year survival in patients with metastatic prostate cancer. J Urol 2003; Makarov DV, Humphreys EB, Mangold LA et al: The natural history of men treated with deferred androgen deprivation therapy in whom metastatic prostate cancer developed following radical prostatectomy. With the Cowboys leading 21-19 and the Colts looking to tie it up with a two-point conversion, Bland broke up a pass at the goal line to keep the Cowboys in the lead and the rout was on after that. Grier is currently on the practice squad, as was Cooper Rush last week. But Bland's biggest play of the game doesn't even out on the stat sheet. In a retrospective analysis of a single-institution cohort of men with mCRPC, pathogenic germline BRCA2 variants were noted in 8 of 141 participants. Brown throws shade at Titans in since-deleted tweet, Derrick Henry tramples Texans again; breaks record set by Eddie George. CeeDee has got to improve and work his way into being the No. In the phase 3, double blind AFFIRM study, Scher et al. It is also not clear if cabazitaxel given directly after docetaxel would be preferred over using ART therapy next, especially if the patient has never received next generation ART therapies such as abiraterone acetate or enzalutamide. Lancet Oncol 2016; Ryan CJ, Crawford ED, Shore ND et al: The IMAAGEN study: effect of abiraterone acetate and prednisone on prostate specific antigen and radiographic disease progression in patients with nonmetastatic castration resistant prostate cancer. --------------------------------------- Jourdan Lewis, Height: 5-10Weight: 195 lbsCollege: Michigan. "I don't have anything definitive there," he told 105.3FM the Fan. Tua Tagovailoas scary head injury: The second-year quarterback suffered a concussion that induced a fencing response. J Clin Endocrinol Metab 2005; Morote J, Orsola A, Abascal JM et al: Bone mineral density changes in patients with prostate cancer during the first 2 years of androgen suppression. Click here for the full injury report for the Cowboys and Bucs. Cancer Res 2011; Hussain M, Fizazi K, Saad F et al: Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer. For Shepley, it'll be about finding a way to show he can be productive on the interior offensive line. The longer recovery timeline still hadHenry on track for a playoff return, so it seems that the Titans had an eye onmaking sure his foot was fully healed before activating him. Nicknamed "Super Cam", he is the NFL leader in quarterback rushing touchdowns and second in quarterback rushing yards.Newton had a Significant improvements in QOL measurements were reported in the patients treated with radium-223. Air can be introduced into the circulation during surgical procedures, lung over-expansion injury, decompression, and a few other causes.Air embolisms may also occur in the xylem of vascular plants, "He actually had a plate and screws to stabilize it, so they made a little bit bigger incision," Watson said. --------------------------------------- Sept. 5 UpdatesMichael Gallup. A Jones fracture is a type of fracture in your foot. N Engl J Med. Lancet Oncol 2015; Ryan CJ, Smith MR, de Bono JS et al: Abiraterone in metastatic prostate cancer without previous chemotherapy. PSADT should be calculated for men with a rising PSA in the setting of ongoing ADT (castration-resistance) as PSADT is useful in determining which men are at highest risk of developing metastatic lesions or dying from prostate cancer.104PSADT <10 months was used to identify the highest risk population for inclusion in the three trials that led to approval of the AR antagonists for men with nmCRPC and is recommended to consider when adding one of the medications to ADT in men with nmCRPC. Expected return: Two to three weeks. Enrollment was restricted to patients with ECOG performance status scores of 0 or 1 who were asymptomatic or minimally symptomatic; patients with visceral metastases were excluded. Endocrine 2014; Watts NB, Adler RA, Bilezikian JP et al: Osteoporosis in men: an Endocrine Society clinical practice guideline. 2:40 p.m. - Cornerback Jourdan Lewis was not practicing during the open portion Wednesday, still recovering from the hamstring strain he suffered during a joint practice with the Chargers two weeks ago. They aren't exactly the same, as Henry had more opportunities and was more productive on a per-game basis in 2021, but his efficiency has allowed him to produce at a nearly identical rate despite fewer carries in 2022. --------------------------------------- CeeDee Lamb, Height: 6-2Weight: 200 lbsCollege: Oklahoma. Cancer 2017; Rodrigues DN, Rescigno P, Liu D et al: Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer. But that will probably be for the last time. Urology 1993; Denis LJ, Keuppens F, Smith PH et al: Maximal androgen blockade: final analysis of EORTC phase III trial 30853. The Cowboys will have Tyron Smith back at practice Wednesday, Mike McCarthy said. Time to first skeletal-related event (SRE) improved from 9.8 month with placebo to 15.6 months with radium-223 (HR=0.66; 95%CI 0.52 to 0.83; P<0.001). in Table 3. This tool can be used with or without measurement of bone mineral density. randomly assigned 1,207 men in a 2:1 ratio to receive apalutamide (240 mg per day) or placebo. He finished Week 1 with five combined tackles to go along with his INT. Urology 2010; Kunath F, Grobe HR, Rucker G et al: Non-steroidal antiandrogen monotherapy compared with luteinizing hormone-releasing hormone agonists or surgical castration monotherapy for advanced prostate cancer: a Cochrane systematic review. Klopp said Jones was the closest to make his return before the latest two injuries, having made his return to full training on October 6. Specifically, cancer-specific survival among men found to be harboring a BRCA2 mutation was found to be half of that among men without a defect in DDR (17.4 versus 33.2months, p=0.027).118Mutations in tumor suppressor genes have also been found to be associated with adverse outcomes among men with prostate cancer. Eur J Cancer 2015; Fu AZ, Tsai HT, Haque R et al: Mortality and androgen deprivation therapy as salvage treatment for biochemical recurrence after primary therapy for clinically localized prostate cancer. Analysis of other secondary endpoints, such as decreased risk of radiographic progression or death, favored enzalutamide with a 76% risk reduction (HR= 0.24; 95%CI 0.10 to 0.56). Should Kearse miss any amount of time, Wilson will be looked upon to help Hooker keep the safety unit churning in the right direction, and to help mentor young talent such as rookie Markquese Bell and second-year safety Israel Mukuamu. As such, it is recommended that a baseline laboratory and imaging assessment be performed to inform discussions around prognosis and clinical decision-making. But if Dorance Armstrong is getting overshadowed by fans and media, that's not the case for his head coach. 10:46 a.m. - Michael Gallup continues to progress in his recovery from a torn ACL suffered in 2021 in "outstanding" fashion, as owner and general manager Jerry Jones labeled it on Friday, but the Hall of Famer wanted to clear the air on recent comments regarding the Super Bowl that were viewed as a hint that Gallup is potentially ready to play in the regular season opener - the veteran wideout still needing some time to become game-ready. Cancer 2005; Cosman F, de Beur SJ, LeBoff MS et al: National Osteoporosis Foundation. He remains on injured reserve for now, unable to return until Week 5 at the earliest, and would be a welcome addition for a Cowboys receiving group that floundered out of the gate but could soon see Washington join a nearly-ready Michael Gallup on the field with Cooper Rush and eventually Dak Prescott. Written and directed by Filipino Canadian filmmaker Kathleen Jayme, the sports documentary 'The Grizzlie Truth' seeks to uncover the truth behind the abrupt move of Vancouver's first and only NBA team to Memphis Read The potential importance of germline and somatic tumor testing, covered in guideline statements 13 and 26, largely surrounds their promise for predicting response to PARP inhibitors such as olaparib, rucaparib, niraparib, veliparib, and talozaparib. This is great news for a Cowboys secondary that is suddenly one of the team's biggest strengths under the watchful eye of defensive coordinator Dan Quinn. WebWatch the NFL's Sunday Night Football, NASCAR, Premier League and much more. It is recommended that men with mCRPC undergo conventional imaging at least annually owing to the fact that, in patients with mCRPC treated with enzalutamide prior to chemotherapy in the PREVAIL trial, radiographic progression occurred in 24.5% of patients without PSA progression, suggesting that routine imaging can identify a significant portion of patients with radiographic progression who would otherwise not be identified.105The precise timing of imaging among men with mCRPC should be determined by multiple factors including biochemical response to treatment, change in disease-related symptoms, and patient preference. Expert Opin Drug Metab Toxicol 2015; Saad F, Gleason DM, Murray R et al: Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. Because men who need dental extractions while on these agents are at higher risk for ONJ, clinicians should consider evaluation by a dentist prior to initiation. WebGet the latest celebrity news and hot celeb gossip with exclusive stories and pictures from Us Weekly. Lamb will get a chance to redeem himself when the Bengals claw their way onto the field in Week 2, but the degree of difficulty has increased by way of injury to Prescott's throwing hand that could sideline him for several weeks. Citations may include links to full text content from PubMed Central and publisher web sites. Furthermore, clinicians should consider known differences in biochemical response to treatment among different therapies for mCRPC when determining the interval between imaging studies. At the time of planned interim analysis, the median OS was 18.4 months in the enzalutamide group versus 13.6 months in the placebo group (HR for death in the enzalutamide group= 0.63; 95%CI 0.53 to 0.75; P<0.001). Derrick Henry injury timeline: How Titans RB returned to form after recovering from 2021 foot injury, Stats, highlights from Derrick Henry's unreal high school football career, A.J. In the absence of Barr, it's been rookie fifth-round pick Damone Clark seeing a surge in reps following his return from neck surgery. Nov. 1: Mike Vrabel confirms that Henry will be sidelined by doesn't give an update about his timetable report. Lancet. 2, the same as cornerback Jourdan Lewis, who will keep his number. There are several retrospective single-arm studies demonstrating safety and feasibility, and many studies from large population-based registries show that improved survival is associated with local control in metastatic prostate cancer patients.152-154However, not all studies have found a survival benefit, and all of these reports should be considered hypothesis-generating as they have unknown biases that make it difficult to apply the data to clinical practice. And it's not just making plays on defense, Armstrong also has a blocked punt and blocked field goal this year on special teams. He'll simply need to build momentum going forward, because the better he can be at his position, the more dangerous the secondary - as a unit - can become in Dallas. Lewis has not gone on short-term injured reserve, though, which indicates the Cowboys are optimistic he won't miss much more time. Out since: September 7 --------------------------------------- Connor McGovern, Height: 6-5Weight: 308 lbsCollege: Penn State. Gallup has come on strong as of late as he continues to ramp up following his return from injury, reeling in several critical receptions that helped consistently move the chains for Dak Prescott in the Thanksgiving victory over the Giants. You fill in the order form with your basic requirements for a paper: your academic level, paper type and format, the number of pages and sources, discipline, and deadline. Theres more out of the Southwest Division: Grizzlies All-Star point guard Ja Morant has been fined by the NBA to the tune of $35K, the league announced in a press statement (Twitter link). And it was reported on Monday evening that the Colombian will now be sidelined for six weeks, meaning he wont be back available until after the World Cup. J Nucl Med 2019; Fendler W, Calais J, Eiber M et al: Assessment of 68Ga-PSMA-11 PET accuracy in localizing recurrent prostate cancer: a prospective single arm trial. Wide receiver Michael Gallup (knee) has been ruled out of Sunday's game as he inches closer to a return from offseason knee surgery. 2:11 p.m. - Michael Gallup isn't putting a timetable on his return to practice and game action. Until these trials are completed, use of PET imaging beyond identifying visible disease in patients with PSA recurrences is considered experimental. MORE: A.J. Alexander-Arnold played the remainder of the first half after an inversion ankle sprain midway through, but swelling and pain prevented him from coming out for the second half at Arsenal. In addition to demonstrating that denosumab was non-inferior to zoledronic acid (20.7 versus 17.1 months, p=0.0002), this trial also showed that denosumab was superior to zoledronic acid in improving time to first SRE in a secondary analysis (p=0.008). Both returned to practice on Friday, however, and though it was in a limited capacity, it supports the expectation that they'll take the field in Week 13 - along with Diggs saying he "feels a lot better" than earlier in the week - while DeMarcus Lawrence is a full-go with injury designation at all on Friday. In the TOPARP-A trial, heavily-treated mCRPC patients treated with olaparib were much more likely to respond in the setting of a DDR alteration.39 The response rate was 88% in biomarker positive patients and 6% in biomarker negative patients. That was just a day after the injury was revealed, so the Titans wasted no time getting him treatment and giving him a chance to return. "Michael's done an excellent job of hitting those (injury rehab) targets and I think we're kind of in the final stages here," head coach Mike McCarthy said. "I'm going to go to the center of the defensive line," Jones told 105.3 FM the Fan on Tuesday morning. If he crosses that hurdle today, then hopefully we'll do more next week," McCarthy said. Injury: Calf Germline mutations in genes involved in DNA damage repair (DDR) have been identified in over 11.8% of men with metastatic prostate cancer, with the most commonly identified gene mutations being BRCA2, CHEK2, ATM, and BRCA1.80 Germline mutations have been found to portend poor prognosis among men with metastatic prostate cancer. 8:42 a.m. - It'll be a late-week decision on Dalton Schultz's availability for the coming divisional matchup against the New York Giants on Monday night. 7:48 p.m. - Starting left tackle Connor McGovern injured his ankle on the Cowboys' first offensive series against the Bucs and is questionable to return to Sunday's game. Several key areas of future research need emphasis to improve clinical care and provide a path to better patient outcomes with advanced prostate cancer. Treatment with enzalutamide plus ADT was associated with a 27% lower risk of death versus placebo plus ADT (HR=0.73; 95%CI 0.61 to 0.89; P=0.001).106Adverse events as the primary reason for treatment discontinuation occurred in 87 patients (9%) receiving enzalutamide compared to 28 (6%) receiving placebo. Surgery is also used for people who use their hands for minute motor skills, such as playing the piano. 2004; Beland G, Elhilali M, Fradet Y et al: A controlled trial of castration with and without nilutamide in metastatic prostatic carcinoma. Eur J Nucl Med Mol Imaging. With their two available practice squad elevations, the Cowboys elevated quarterback Will Grier and rookie center Alec Lindstrom. As he enters his sixth season in the league, the 28-year-old, "Grinding it out in the offseason and preseason to get that job," said Rush. Diggs and Gallup were officially listed as questionable on the final injury report, along with Jayron Kearse, Quinton Bohanna, and Anthony Barr, the latter three expected to play as well which will mark a return from injury for Barr - his first game action since hurting his hamstring in Week 8, assuming no setbacks in Saturday's practice to come. J Clin Oncol 2017; Armstrong AJ, Halabi S, Luo J et al: Prospective multicenter validation of androgen receptor splice variant 7 and hormone therapy resistance in high-risk castration-resistant prostate cancer: the PROPHECY study. TBI in children. Lewis has been dealing with a hamstring strain suffered during a joint practice with the Chargers in mid-August, but Cowboys head coach Mike McCarthy said the team feels good about where his in his recovery from the injury. Osteoporosis-related fractures were also reduced among patients treated with bisphosphonates (RR=0.80; 95%CI: 0.69 to 0.94; NNT to prevent one additional fracture: 167). Cancer Res 2008; Mohler JL, Titus MA, Bai S et al: Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer. This will serve the Cowboys well both now and when Kearse returns - because the more special players on the roster, the better. J Urol 2018; Sweeney CJ, Chen YH, Carducci M et al: Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. 9. However, in a single arm study of 131 men with nmCRPC at high risk of developing metastatic disease as identified by a PSADT of <10 months, patients treated with abiraterone acetate plus prednisone had a PSA significantly reduced by > 50% in 86.9% of cases (p<0.0001).109Additionally, median time to PSA progression was 28.7 months (95%CI 21.2 to 38.2). He notched two more sacks on Tom Brady, putting him in elite company to begin his career. N Engl J Med. Eur Urol 2015; Scher HI, Lu D, Schreiber NA et al: Association of AR-V7 on circulating tumor cells as a treatment-specific biomarker with outcomes and survival in castration-resistant prostate cancer. Unlike the other major urologic neoplasms such as renal cell and urothelial cancers where next generation immunotherapy agents (check point inhibitors and anti-CTLA-4 agents) have demonstrated meaningful activity, there has been limited evidence of the utility of these therapies in mCRPC. Similarly, denosumab has been administered as 60mg every 6 months for osteoporosis compared to 120mg monthly for SRE prevention. Tua Tagovailoas scary head injury: The second-year quarterback suffered a concussion that induced a fencing response. It's also worth noting that the surgery Henry had to repair the Jones fracture was a bit different than most surgeries of that nature. Cancer 2013; Mateo J, Carreira S, Sandhu S et al: DNA-repair defects and olaparib in metastatic prostate cancer. J Clin Oncol 2006; Harshman LC, Chen YH, Liu G et al: Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel. Last week, Cowboys owner/GM Jerry Jones indicated that Gallup won't have to start the season on PUP, which requires a minimum four-game stay on the reserve list. Participants randomized to receive abiraterone acetate plus prednisone had statistically significant improvement in radiographic PFS (HR=0.53 p<0.001), as previously reported during interim analyses.120The final analysis of OS showed a statistically significant increase in patients treated with abiraterone acetate plus prednisone (HR=0.81; 95%CI 0.70 to 0.93; P=0.0033).119The most common grade 3-4 adverse events were cardiac disorders (8% in the abiraterone acetate group versus 4% in the placebo group), increased alanine aminotransferase (6% versus <1%), and hypertension (5% versus 3%). Gallup was again a limited participant in practice this week but progressed to seven-on-seven drills after doing only individual drills last week. Oct. 31: After the game, it is revealed that Henry will get an MRI to look at his foot injury on Monday. J Urol. ------------------------------------ Dorance Armstrong, Height: 6-4Weight: 255 lbsCollege: Kansas. McGovern limped off the field with help from the Cowboys' athletic training staff, but soon returned to the sideline testing out the ankle. November 15, 2022 -- No matter the sport you are watching, you have probably seen some injuries on the field. Tarell Basham was initially ruled out as well but having now been moved to IR for the signing of Cooper Rush to the active roster negates the need to list him as inactive, and it is instead linebacker Jabril Cox joining Tolbert in not suiting up for a second consecutive game as he continues to ramp up from a torn ACL suffered in 2021; and cornerback Nahshon Wright rounds out the list. The As the Cowboys continue to shuffle the roster and practice squad over the week, the full list of changes will be announced by Monday. Children might be unable to let others know that they feel different following a blow to the head. J Clin Oncol 2014; Tang C, Hoffman KE, Allen PK et al: Contemporary prostate cancer treatment choices in multidisciplinary clinics referenced to national trends. Player safety is one of the most important things when you are in As expected, the Cowboys elevated kicker Brett Maher and backup quarterback Cooper Rush from the practice squad ahead of Sunday's season opener against the Bucs. N Engl J Med 2019; Grasso CS, Wu Y-M, Robinson DR et al: The mutational landscape of lethal castration-resistant prostate cancer. In addition to laboratory and imaging parameters, performance status and the extent of disease-related symptoms are strongly associated with mortality. I played with him a lot during the summer. A rookie defensive tackle from Arkansas, Ridgeway spent the first week of the season on the 53-man roster but was waived on Saturday to make space for players needed for injuries. That means Lamb will have to find chemistry with backups Cooper Rush and Will Grier - Rush to get the initial nod as starter - to help lead a WR unit that looked completely out of sorts in the regular season opener. About Advertising Contact Privacy Terms, Nunez return & injury updates 4 key things from Jurgen Klopps post-Lyon press conference, Jurgen Klopp admits new Luis Diaz injury is proper smash in the face, Going to be special Liverpool fans impressed by youngster in Lyon defeat, Jurgen Klopp gives Harvey Elliott injury update after early substitution, Liverpool 1-3 Lyon: Reds defeated as 24 players feature in friendly, Elliott injury worry & returning faces 5 talking points from Liverpool 1-3 Lyon, Liverpool FC and the lure no other club can offer, The 6-figure Liverpool signings who could save the club millions, Being a Liverpool fan today and the value of taking a step back. Fine aside, the 63 lead guard out of Murray State is having a terrific fourth season for the 13-9 Grizzlies thus far, averaging a career-high 28.2 PPG on .460/.366/.743 shooting splits. Having him play all the positions, we treated him like we did with CeeDee (in 2020).". Jan. 5: The Titans officially designate Henry to return from IR, giving him three weeks (21 days) to be activated to the 53-man roster. They'll also have to explain to the six-time All-Pro what his role with the team would be in 2022, considering rookie first-round pick Tyler Smith is expected to start at left tackle against the Tampa Bay Buccaneers in Week 1 following injury to Tyron Smith. The four-time Pro Bowl linebacker was back at practice on Wednesday though, a limited participant working his way back onto the field with the goal of suiting up this weekend against the Indianapolis Colts. It is Matips second injury absence of the season after missing the clashes against Crystal Palace, Man United and Bournemouth. Out since: Arsenal (A) Platinum-based chemotherapy also has a mechanism of action that correlates with defects in homologous recombination DNA repair. And that's what we wanted.". This is Gallup's first practice since undergoing knee surgery in February to repair a torn ACL. Calais J, Ceci F, Eiber M et al: 18F-fluciclovine PET-CT and 68Ga-PSMA-11 PET-CT in patients with early biochemical recurrence after prostatectomy: a prospective, single-centre, single arm, comparative imaging trial. Osteoporos Int 2014; Serpa Neto A, Tobias-Machado M, Esteves MA et al: Bisphosphonate therapy in patients under androgen deprivation therapy for prostate cancer: a systematic review and meta-analysis. Investigators noted that anemia and nausea were the main toxic effects seen in patients on olaparib. ------------------------------------ Mike McCarthy, College: Baker UniversityHometown: Pittsburgh, PA. 10:44 a.m. - Odell Beckham, Jr. is currently on a bit of a tour as he works through the process of determining his next NFL home, and the Cowboys now know exactly when he'll visit Dallas - the meeting to occur in-person on Monday, Dec. 5, following the team's Week 13 matchup against the Colts. The primary endpoint was imaging-based PFS in cohort A. Nov. 2: The Titans officiallysign Adrian Peterson and D'Onta Foreman to the practice squad. A PSA response occurred in 35.7% and 13.5% of the patients, respectively (P<0.001), and tumor response was noted in 36.5% and 11.5% (P=0.004). During the first interim analysis of OS, 103 patients (11%) in the enzalutamide group and 62 (13%) in the placebo group had died. ------------------------------------ Trevon Diggs. Jonathan Taylor likely "Doing very well," said McCarthy. Just keep getting better every day.". In the Week 1 loss to the Buccaneers at AT&T Stadium, the former first-round pick was not in Pro Bowl form - to say the very least - ending the contest with just two catches for 29 yards on 11 targets. He won't be out there, more than likely, against Tampa.". --------------------------------------- Sept. 13 UpdatesWill Grier, Height: 6-1Weight: 220 lbsCollege: West Virginia. The medical department has been busy and will continue to be, but what is the current injury situation at Anfield for the likes of Andy Robertson, Arthur and the newly injured trio? The rate of pathologic fractures was also lower compared to placebo (13.1% with zoledronic acid versus 22.1% for placebo). As of June 2017, a total of 219 patients (23%) in the enzalutamide group had metastases or had died, as compared with 228 (49%) in the placebo group. A muscle injury on the eve of Rangers Champions League visit has spelt the end of Arthurs 2022, after undergoing surgery on the issue. J Urol 1999; Odewole O, Tade F, Nieh P et al: Recurrent prostate cancer detection with anti-3(18)F-FACBC PET/CT: comparison with CT. Eur J Nucl Med Mol Imaging 2016; Nanni C, Zanoni L, Pultrone C et al: 18F-FACBC versus 11C-choline PET/CT in prostate cancer relapse. CA Cancer J Clin 2019; Moreira DM, Howard LE, Sourbeer KN et al: Predicting time from metastasis to overall survival in castration-resistant prostate cancer: results from SEARCH. The use of radium-223 for the treatment of bone metastases relies on the chemical similarity to calcium and the ability of the -radiation and the short-lived decay products of radium-223 to kill cancer cells. Tennessee likely did this with the playoffs in mind, as it bought Henry a couple of extra weeks to heal before their game as the No. All secondary endpoints, including time to PSA progression, PFS, and PSA response rate favored the abiraterone acetate group. Optimal third line therapy for mCRPC is unknown. Lancet. Accessed on August 15, 2018. A muscle injury on the eve of Rangers Champions League visit has spelt the end of Arthurs 2022, after undergoing surgery on the issue. Median OS was not reached in either group. The study concluded that early treatment with zoledronic acid in men with HSPC and bone metastases was not associated with lower risk for SREs or death. But the Cowboys can elevate players on Saturday before the game. In addition to monitoring PSA, routine use of conventional imaging should be integrated into monitoring the disease status of men with nmCRPC. 2:52 p.m. - Only two players are listed on the Cowboys' first official injury report of the season: wide receiver Michael Gallup (knee) and cornerback Jourdan Lewis (hamstring). Docetaxel is an effective option in both mCRPC and mHSPC and should be considered as standard first-line chemotherapy in the setting of mCRPC.19,20 Cabazitaxel was approved as second line chemotherapy in 2010 based on the results of the TROPIC trial.24 TROPIC randomized 755 men with mCRPC who had previously received docetaxel chemotherapy and demonstrated median survival of 15.1 months (95%CI 14.1 to 16.3) in the cabazitaxel group and 12.7 months (11.6 to 13.7) in the mitoxantrone group. N Engl J Med. He knows the system. Trevon Diggs and Michael Gallup both missed practice on Wednesday with illness, though they are the only two who did - a drastic reduction in how many battled the virus as recently as two two weeks ago. 2016; Montgomery RB, Mostaghel EA, Vessella R et al: Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Lancet Oncol 2020; Alexandrov LB, Nik-Zainal S, Wedge DC et al: Signatures of mutational processes in human cancer. 2 jersey. J Nucl Med 2018; Akin-Akintayo OO, Jani AB, Odewole O et al: change in salvage radiotherapy management based on guidance with FACBC (fluciclovine) PET/CT in postprostatectomy recurrent prostate cancer. Secondary endpoints including time to symptomatic progression (HR= 0.45; 95%CI 0.32 to 0.63; P<0.001) and time to metastasis (HR=0.27; 95%CI 0.22 to 0.34, p<0.001) were significantly longer in the apalutamide arm compared to placebo. Has a great motor, his ability to make plays he's as good of a defensive player as we have on our roster.". "Grier got slowed there right at the end with a hamstring issue. We need to get past these seven days, then we'll have a better idea.". Henry continues to be one of the best running backs in the league. Eur Urol. Out since: October 4 Nov. 1: ESPN's Adam Schefter reports that Henry's season could be in jeopardy as a result of his foot injury. [He] twisted the ankle, not good. There is a lack of evidence suggesting benefit, and these agents, like any medication, have associated toxicity. In addition to PARP inhibitors, immunotherapies have also emerged as a key therapeutic modality in a large number of solid tumors. Compromised MMR results in microsatellite instability and a hypermutator phenotype that has been associated with chemotherapy resistance but immunotherapy sensitivity.131, In a case series of 1,033 patients with advanced prostate cancer 3.1% had a microsatellite instability-high (MSI-H)/mismatch repair deficient (dMMR) prostate cancer, with more than half of those treated with anti PD-1 therapy responding to treatment having a >50% decline in PSA.132. "That's all up to the trainers," he said at last week's Season Kickoff Event. WebAn air embolism, also known as a gas embolism, is a blood vessel blockage caused by one or more bubbles of air or other gas in the circulatory system. Dec. 12: Rapoport reports that Henry will have a chance to return if the Titans make the playoffs or face a win-and-in scenario in Week 18. Below is a look at his total numbers from each of the last two seasons: Certainly, those are eerily similar. Median survival in the docetaxel plus prednisone every three weeks group was 18.9 months compared to 16.5 months in the mitoxantrone group. Phase II trials have been designed and executed to determine if there is an impact on the biology of disease. But McCarthy said special teams is what is currently holding Tolbert back, stating that playing all the positions at receiver didn't allow him much time to learn the spots in the kicking game. He is on pace to lead the NFL in carries for the third time in four seasons and will almost certainly record double-digit rushing touchdowns for the fifth consecutive season. ", ------------------------------------ Dec. 1 UpdatesTerence Steele, Height: 6-6Weight: 310 lbsCollege: Texas Tech. Eur Urol Oncol 2018; Garcia-Albeniz X, Chan JM, Paciorek A et al: Immediate versus deferred initiation of androgen deprivation therapy in prostate cancer patients with PSA-only relapse. Rates of hypocalcemia were higher with denosumab than zolendronic acid; as such, clinicians should monitor calcium levels prior to infusions, and repletion of vitamin D prior to starting these agents, along with SOC calcium and vitamin D maintenance. The foot injury will not be an issue for Henry, but he showed glimpses of decline pre-injury. As things get underway on Wednesday, Lewis will again be a full go in practice - a strong sign he experienced no setbacks following Monday's work. 4:25 p.m. - After a productive week returning to practice on a limited basis, wide receiver Michael Gallup could progress to some group drills this week, head coach Mike McCarthy said. Multidisciplinary clinics and the resulting multimodality treatment approaches can optimize treatment selection, maximize results and minimize overtreatment and side effects.151Many clinical trials are evaluating the concepts of integrating systemic therapy with radiation and/or surgery, such as optimizing treatment of men with locally advanced primary tumors, assessing the benefit of local therapy in men with metastatic disease, or determine the impact of metastasis-directed therapy in the oligometastatic setting. Median survival in the sipuleucel-T arm was 25.8 months compared to 21.7 months in the placebo arm. Henry suffered a broken foot during the Titans vs. Colts game in Week 8 of the 2021 NFL season. Osteoclast-targeted agents were studied in men with mCRPC and bone metastases. Gallup practiced on a limited basis again Thursday. Other multiple numbers include No. Expect several number changes over the next few days, including Turpin, who is expected to wear No. "Let's get over that hurdle first," McCarthy said. The veteran cornerback is working through a hamstring tweak suffered in mid-August, but while he had already returned to doing individual drills at practice, he hadn't yet been cleared to return to team reps. That changed on Monday, per head coach Mike McCarthy, who confirmed Lewis' appearance in team drills earlier this week. After progression to CRPC, all patients crossed over to open-label zoledronic acid. Nat Rev Clin Oncol. J Clin Oncol 2002; Castro E, Romero-Laorden N, Del Pozo A et al: PROREPAIR-B: a prospective cohort study of the impact of germline DNA repair mutations on the outcomes of patients with metastatic castration-resistant prostate cancer. Recommendations include weight bearing exercises, muscle building exercises, balance exercises, smoking cessation, reduction of alcohol intake, and adequate intake of calcium and vitamin D.144The estimated daily calcium requirement is 1,000 mg to 1,200 mg from food and supplements. I feel like I am a starter in this league. With three touchdown throws Sunday night against the Colts, Prescott broke hist tie with Roger Staubach (153), and then not only tied Danny White (155), but passed him with his third TD throw in the second half. Kelvin Joseph, the former second-round pick expected to take a step forward in his development in 2022, returned to practice on Monday. If not, that means Gallup could be ready to return to the lineup sometime in September or early October. "The goal is to hopefully get him out there on Monday he's doing really well.". Men receiving bisphosphonates had significantly reduced risk of osteoporosis (RR= 0.39; 95%CI: 0.28 to 0.55; number needed to treat [NNT] to prevent one additional patient with osteoporosis: 2.82). Washington suffered a broken foot in the first week of camp back in July and has been on IR ever since. WebHeadache, dizziness, confusion, and fatigue tend to start immediately after an injury, but resolve over time. Response to treatment and/or disease progression among men with mCRPC may be evaluated through PSA testing, imaging, or change in disease-related symptoms. Prostate Int. In need of a fullback, Gifford was inserted into a goal-line package, leading the way for Tony Pollard's 1-yard touchdown run in the first quarter. He returns to the game but racks up 68 rushing yards on 28 carries for a season-low 2.4 yards per carry. He looks a lot more explosive and powerful than he did after returning from injury to play in the team's lone playoff game of last season. --------------------------------------- Sept. 18 UpdatesDorance Armstrong. N Engl J Med 1998; Ansari MS, Gupta NP, Hemal AK et al: Combined androgen blockade in the management of advanced prostate cancer: a sensible or ostensible approach. When Derrick Henry went down with a foot injury during the 2021 NFL season, many wondered just how much that would impact him. That will answer itself. --------------------------------------- Aug. 30 UpdatesTrysten Hill. --------------------------------------- Aug. 29 UpdatesMichael Gallup. A second-round pick of the Steelers in 2018, Washington signed a 1-year deal with the Cowboys this offseason in free agency. Yet, Jalen Tolbert was no active for Sunday's game with the Bucs, passed over by an undrafted rookie and a fifth-round pick from last year. Joseph had a mostly solid camp in his second offseason with defensive coordinator Dan Quinn and cornerbacks coach Al Harris, at times showing the coverage ability that led to the Cowboys giving him the nod early on Day 2 in the 2021 NFL Draft. Preliminary data have demonstrated that, similar to PARP inhibition, carboplatin may improve outcomes in men with similar DNA defects.130However, to date there are no randomized data supporting its use. "I thought his workout was excellent really the last two days," head coach Mike McCarthy said. The Grizzlies were 9-4 when Bane was injured in a Nov. 11 game against the Timberwolves. Fizazi et al.148performed a non-inferiority trial of 1,904 men with mCRPC with bone metastases randomized to receive denosumab or zoledronic acid with the primary endpoint of outcome of time to SRE. A 2016 study examining the injury in NFL athletes placed the average return-to-play timeline at 11.1 months. The starting right tackle was absent from practice on Thursday with illness, one day after both Trevon Diggs and Michael Gallup were tasked with going virtual because of it. 4:21 p.m. - Wednesday marked another milestone in Michael Gallup's recovery from February knee surgery, as the fifth-year receiver practiced on a limited basis for the first time since tearing his ACL in January. 8:41 a.m. - There are some very difficult decisions awaiting the Cowboys on Tuesday, and they have only until 4 p.m. N Engl J Med 2004; Scher HI, Fizazi K, Saad F et al: Increased survival with enzalutamide in prostate cancer after chemotherapy. 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